A schematic representation of the mechanism of toxicity of paraquat (PQ) and diquat (DQ). 1 = redox cycling of paraquat or diquat utilising NADPH; 2 =

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A schematic representation of the mechanism of toxicity of paraquat (PQ) and diquat (DQ). 1 = redox cycling of paraquat or diquat utilising NADPH; 2 = dismutation of superoxide anion to hydrogen peroxide (H2O2); 3 = formation of hydroxyl radical leading to lipid peroxidation; 4 = detoxification of H2O2 via catalase and glutathione reductase/peroxidase couple, utilising NADPH. Based on Smith.3 (GSSG = glutathione (oxidised form); GSH = glutathione (reduced form); O2 = oxygen). A schematic representation of the mechanism of toxicity of paraquat (PQ) and diquat (DQ). 1 = redox cycling of paraquat or diquat utilising NADPH; 2 = dismutation of superoxide anion to hydrogen peroxide (H2O2); 3 = formation of hydroxyl radical leading to lipid peroxidation; 4 = detoxification of H2O2 via catalase and glutathione reductase/peroxidase couple, utilising NADPH. Based on Smith.3 (GSSG = glutathione (oxidised form); GSH = glutathione (reduced form); O2 = oxygen). S A M Saeed et al. Postgrad Med J 2001;77:329-332 Copyright © The Fellowship of Postgraduate Medicine. All rights reserved.