Increased μ-opioid receptor expression in metastatic lung cancer

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Increased μ-opioid receptor expression in metastatic lung cancer P.A. Singleton, T. Mirzapoiazova, R. Hasina, R. Salgia, J. Moss British Journal of Anaesthesia Volume 113, Pages i103-i108 (July 2014) DOI: 10.1093/bja/aeu165 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 MOR immunohistochemical staining intensity increases with NSCLC tumour stage and lymph node metastasis in patient samples. Patient NSCLC adenocarcinoma lung cancer samples were acquired from paraffin-embedded, formalin-fixed tissue archived at The University of Chicago (Chicago, IL, USA) Human Tissue Resource Center. Immunohistochemistry for human MOR was conducted on tissue sections and images were captured at ×20 or ×40 using a Fisher Scientific Micromaster digital microscope and the Micron USB live-field capture software. MOR staining intensity increases with cancer stage (a–d). The pattern of MOR staining appears to change from a nuclear (a) to cytosolic (b) to a cytosolic/membrane cellular localization (c and d). MOR staining intensity is also increased in metastatic lymph nodes (e vs f). British Journal of Anaesthesia 2014 113, i103-i108DOI: (10.1093/bja/aeu165) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Graphical representation of the average MOR immunohistochemical staining intensity of normal adjacent, total lung cancer, and subset of lung cancer with lymph node metastasis patient samples. MOR immunohistochemistry was performed on de-identified normal adjacent control and lung cancer patient samples, scored by two independent pathologists on a four-point scale (0, 1, 2, 3) and box plots were generated as described in the Methods. There was a statistically significant difference between normal adjacent control and total lung cancer (P=0.0242) and also total lung cancer and subset of lung cancer with lymph node metastasis (P=0.0013). British Journal of Anaesthesia 2014 113, i103-i108DOI: (10.1093/bja/aeu165) Copyright © 2014 The Author(s) Terms and Conditions