Figure 5 Multiple immunohistochemistry for various RNA-binding proteins and VCP/p97 Representative microphotographs of transverse cryosections from the.

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Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Evidence of Multisystem Disorder in Whole-Brain Map.

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Figure Pedigrees of the SCA42 families identified in this study

Figure 2 ALSFRS-R changes (A) Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) slope after 6 months of treatment without (left)

Figure 3 Pedigree of familial idiopathic transverse myelitis

Figure 1 Muscle biopsy from a patient with a slowly progressive (24 years) HMGCR antibody–associated myopathy syndrome (A) Hematoxylin & eosin stain, (B)

Figure 2 GlyR antibody binding

Figure 2 Needle biopsy of the left vastus lateralis

Proinsulin effect on cardiac expression markers.

ERM proteins are essential for efficient cell‐to‐cell spread of Listeria. ERM proteins are essential for efficient cell‐to‐cell spread of Listeria. (A–D)

Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.

Figure 3 Immunohistochemical analyses of positive and negative Epstein-Barr virus (EBV) control tissues using immunostaining Immunohistochemical analyses.

Figure 2 Disease progression slowed during each round of Treg infusions and correlated with increased Treg suppressive function Disease progression slowed.

Figure 3 LGI1 and Caspr2 immunohistochemistry on rat brain

Figure Sural nerve electron microscopy

Figure 1 Spine MRI, sagittal and axial views of patients with idiopathic transverse myelitis with VPS37A mutations Spine MRI, sagittal and axial views.

Figure 1. MRI features of AP5Z1-associated complicated spastic paraplegia MRI features of AP5Z1-associated complicated spastic paraplegia (A) Periventricular.

Figure DPPX antibodies as detected by fluorescence-based immunohistochemistry and a cell-based assayImmunohistochemistry displayed binding of the patient's.

Figure 2 FXTAS Rating Scale scores for case 1

Figure 2. Ophthalmologic findings of bialleic AP5Z1 mutations

Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque.

Figure 1 Tibialis anterior muscle biopsy of P1 (A) Increased fiber size variation, ring fibers, slight endomysial fibrosis, and prominent clear mainly.

Figure 4 Detection of EBER+ cells in MS and control brains by in situ hybridization Detection of EBER+ cells in MS and control brains by in situ hybridization.

Figure 1 Reactivity of the patients' antibodies with rat brain and HEK cell-based assays Rat hippocampal dentate gyrus neuropils were stained with patient.

Figure 2 Vastus lateralis biopsy of P2 (A) Vastus lateralis muscle cryostat section hematoxylin and eosin (H&E) staining shows basophilic subsarcolemmal.

Figure 2 Histopathologic evaluation of sections of muscle biopsy specimens based on 4 different domains Histopathologic evaluation of sections of muscle.

Figure 2 Brain biopsy Brain biopsy (A) Double staining with anti-aquaporin-4 (AQP4) antibody (dark green) and Luxol fast blue (blue) is shown. Loss of.

Figure Nuclear Nrf2 expression after fumarate therapy A new left occipital fluid-attenuated inversion recovery hyperintense (A), T1 hypointense (B), and.

Figure 2 Neuropathologic examination for lymphoma etiology (patients 1–4)‏ Neuropathologic examination for lymphoma etiology (patients 1–4) Immunohistochemical.

Prion-like Domains Program Ewing’s Sarcoma

Diagnostic Utility of Molecular Investigation in Extraskeletal Myxoid Chondrosarcoma Stefania Benini, Stefania Cocchi, Gabriella Gamberi, Giovanna Magagnoli,

Figure 1 Genetic profile of 90 patients with dysferlin deficiency

Figure 2 Histochemical and immunohistochemical staining and electron microscopic examination of structures in the brain biopsy Hematoxylin & eosin staining.

Figure 2 Histopathologic findings of patients with both inflammatory myopathy and myasthenia gravis Histopathologic findings of patients with both inflammatory.

Figure 3 Temporal trends in FALS incidence

Figure 5 Neurite structure is not disrupted by the lack of neurofilament light (NEFL)‏ Neurite structure is not disrupted by the lack of neurofilament.

Figure Chronic inflammatory demyelinating polyneuropathy–like picture in patient with proven Creutzfeldt-Jakob disease (A) Example of partial conduction.

Figure 3. Structural observations

Figure 1 GABAB expression in the thymus(A–C) Staining of thymus tissue with anti-cytokeratin (A) and anti-GABAB antibody (B, C double immunofluorescence).

Type 1 NSPCs express nestin, ApoE, and GFAP, while mature granule cells make connections with astrocytes expressing ApoE and GFAP. A–D, Representative.

Figure 1 Mutations in SPG7 in a family with primary lateral sclerosis

Figure 3 Detection of JC virus (JCV) genomic DNA in mildly enlarged nuclei of oligodendroglia-like cells Detection of JC virus (JCV) genomic DNA in mildly.

Figure 1 VGCC antibody uptake in cerebellar slice culture

Figure 2 Abnormal myofiber nuclei in HMGCR antibody–associated myopathy Myonuclei are often enlarged (dark arrow) with clear centers (dark arrowhead) or.

Initiation of angiogenic Kaposi's sarcoma lesions

Figure 1 Annual trend in specimen type submitted as first sample for aquaporin-4 immunoglobulin G testing (serum only vs CSF only vs both) from 101,065.

Figure 2 Immunohistological detection of EBV latent and early lytic proteins in MS and control brains Immunohistological detection of EBV latent and early.

Figure 3 Expression of mutant STIM1 in cultured cells and its effect on store-operated Ca2+ influx Expression of mutant STIM1 in cultured cells and its.

DIA1(R1204X) induces elongated and thick microvilli in HeLa cells

Figure 1. Radiologic and pathologic findings

Figure 2 Analysis of muscle and nerve histopathology and muscle mtDNA deletions (A) Representative muscle biopsy shows a cytochrome c oxidase (COX)-negative.

Figure 2 DNM1 mutations inhibit transferrin uptake Inhibition of transferrin internalization in mammalian cell lines. DNM1 mutations inhibit transferrin.

Figure 3 ADAM22 mutant proteins do not bind to LGI1

Figure Clinical, radiologic, and histopathologic findings

Figure 1. Spinal cord MRI and immunofluorescence staining of the patient's serum and controls on different tissues and recombinant cell substrates Spinal.

Figure 4. The N:M ratio is significantly increased in patients with ALS and correlates with disease progression The N:M ratio is significantly increased.

(A) Faucher and Pliska hydrophobicity plot of D2SV protein sequence.

Figure 3 Muscle biopsy showing myofiber atrophy and degeneration

Figure DYNC1H1 mutation in pedigree with dominant spinal muscular atrophy and effect on the dynein complex DYNC1H1 mutation in pedigree with dominant spinal.

Figure 1 Classical pathway and lectin pathway activity in patients with multifocal motor neuropathy and controls Classical pathway (CP) activity (A) and.

Figure 2 Detection of atypical anti-neuronal antibodies Immunohistofluorescence assay on rat brain sagittal slices incubated with the patient's CSF and.

Figure 6 Multiple target epitopes exist in the N-terminal domains of Caspr2 (A) Multidomain deletion constructs of Caspr2 were generated to determine which.

Figure 6 P2Y12 is highly expressed in CD68+ and CD163+ cells during parasitic brain infectionIn a case of Schistosoma mekongi infection, hematoxylin and.

Fig. 1. Lhx1 is expressed in the proximal region of the OV

Figure 2 Compound heterozygous mutations in ADAM22

Figure 3 Bilateral optic atrophy and sural nerve biopsy of patient AII-2 Bilateral optic atrophy and sural nerve biopsy of patient AII-2 (A) Red-free photographs.

Figure 4 Cell count of selective immune cell subpopulations during alemtuzumab Cell count of selective immune cell subpopulations during alemtuzumab Absolute.

Figure 1 Representative radiologic and pathologic images of patients with brain somatic mutations in SLC35A2 Representative radiologic and pathologic images.

Figure 2 Nonhuman primate brain immunohistochemistry

Figure 2. Percentage of CD16− monocytes in the blood is reduced during disease progression Percentage of CD16− monocytes in the blood is reduced during.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

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Figure 5 Multiple immunohistochemistry for various RNA-binding proteins and VCP/p97 Representative microphotographs of transverse cryosections from the specimens of patient III-2 in family 1. Multiple immunohistochemistry for various RNA-binding proteins and VCP/p97 Representative microphotographs of transverse cryosections from the specimens of patient III-2 in family 1. (A–D) Note the perinuclear and subsarcolemmal aggregation of fused in sarcoma/translated in liposarcoma (FUS/TLS) with sparse staining in cytoplasm (arrows), whereas FUS/TLS mislocalization was scarcely observed. (E–H) In atrophic fibers (asterisks), diffuse cytoplasmic expression and extranuclear/subsarcolemmal aggregation of TATA-binding protein–associated factor 2N (TAF15) were frequently found. The aggregation is partially colabeled with ubiquitin (arrowheads). (I–L) In addition to heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and A2B1, Ewing sarcoma breakpoint region 1 (EWSR1) and sequestome-1/p62 (SQSTM1/p62) double-positive aggregation was observed in rimmed vacuoles (arrows). (M–P) Note the multisystem proteinopathy 1–linked valosin-containing protein (VCP)/p97, SQSTM1/p62, and hnRNPA1 triple-labeled aggregates in the rimmed vacuoles (arrows). (Q–T) In atrophic fibers, amyotrophic lateral sclerosis/distal myopathy–linked matrin-3 was aberrantly involved in the subsarcolemmal SQSTM1/p62-positive aggregates (arrowheads). Scale bars = 50 μm. Rumiko Izumi et al. Neurol Genet 2015;1:e23 © 2015 American Academy of Neurology