Self-limited variant of febrile ulceronecrotic Mucha-Habermann disease with polyclonal T-cell receptor rearrangement Peter Helmbold, Gabriele Gaisbauer,

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Presentation transcript:

Self-limited variant of febrile ulceronecrotic Mucha-Habermann disease with polyclonal T-cell receptor rearrangement Peter Helmbold, Gabriele Gaisbauer, Eckhard Fiedler, Markus Stücker, Manfred Wolter, Wolfgang Ch. Marsch Journal of the American Academy of Dermatology Volume 54, Issue 6, Pages 1113-1115 (June 2006) DOI: 10.1016/j.jaad.2006.02.043 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A and B, Ulceronecrotic Mucha-Habermann disease. Patient presented with firm serous blisters, erythematous papules, and adherent necroses measuring 0.5 to 2 cm disseminated on the trunk, extremities, and face. C, Lichenoid inflammatory reaction with lymphocytic infiltration of epidermis leading to necrobiosis of keratinocytes. D, Blastic lymphocytes, some with crenated nuclei or atypical mitoses were accompanied by smaller lymphocytes and neutrophils. E, Erythrocyte extravasation and accumulation of lymphocytes at basal epidermis (arrows). F, Predominant phenotype of dermal and epidermal infiltrating lymphocytes was CD8+ (brownish red). (C-F, Hematoxylin-eosin stain; original magnifications: C, ×40; D, E, ×200; F, ×100; scale bar: C, 500 μm; D, 100 μm; E, 50 μm; F, 200 μm.) Journal of the American Academy of Dermatology 2006 54, 1113-1115DOI: (10.1016/j.jaad.2006.02.043) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions