Network recovery for isoenzymes and protein complexes

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Network recovery for isoenzymes and protein complexes Network recovery for isoenzymes and protein complexes Recovery of enzyme function. Receiver operating characteristic curves obtained for the recovery of Escherichia coli isoenzymes and protein complexes based on the metabolome profiles recorded in single deletion mutants. The area under the curve (AUC) is reported in parentheses.Consistent metabolic patterns in mutants of protein complex subunits. The heatmap shows the pair‐wise similarity (e.g., CLR index) between metabolome response to gene deletions. Genes related to densely connected protein complexes consisting of at least three subunits are selected. We visualized the protein complex adjacency matrix, opportunely reordered. Magnified protein complexes are 1, succinate dehydrogenase; 2, cytochrome bo terminal oxidase; 3, fumarate reductase/phosphate ABC transporter/dipeptide ABC transporter; 4, murein tripeptide ABC transporter; 5, ferric enterobactin transport complex/ferric dicitrate transport system; 6, NADH:ubiquinone oxidoreductase/Tol–Pal cell envelope complex and high‐scoring combinations thereof. Tobias Fuhrer et al. Mol Syst Biol 2017;13:907 © as stated in the article, figure or figure legend