Genetics and Etiopathophysiology of Schizophrenia

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Presentation transcript:

Genetics and Etiopathophysiology of Schizophrenia Janet L. Sobell, PhD, Marci J. Mikesell, PhD, Cynthia T. McMurray, PhD Mayo Clinic Proceedings Volume 77, Issue 10, Pages 1068-1082 (October 2002) DOI: 10.4065/77.10.1068 Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Major pathways of the dopamine system in the brain. CA = caudate; NuAcc = nucleus accumbens; PFC = prefrontal cortex; PUT = putamen; SN = substantia nigra; VTA = ventral tegmental area. Mayo Clinic Proceedings 2002 77, 1068-1082DOI: (10.4065/77.10.1068) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Pedigree of schizophrenia family displaying anticipation. This representative pedigree from the study of Bassett and Honer135 shows the occurrence of anticipation in 8 Eastern Canadian schizophrenia families. GG = grandparental generation; IG = index generation; PG = parental generation. Numbers below each individual indicate their age in years at first hospitalization for psychotic illness. Closed symbols indicate affected individuals; half-closed symbols indicate the presence of schizotypal conditions; open symbols indicate unaffected individuals. Mayo Clinic Proceedings 2002 77, 1068-1082DOI: (10.4065/77.10.1068) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions