CAPP2: Time to first colorectal cancer in those randomized to aspirin compared with those randomized to the aspirin placebo. CAPP2: Time to first colorectal cancer in those randomized to aspirin compared with those randomized to the aspirin placebo. In each case, Kaplan–Meier analysis was restricted to participants who had taken 2 or more years' intervention and the analysis was adjusted for gender (HR 0.41, 95% CI, 0.19–0·86, P = 0·02). Each point on the plot shows the estimated cumulative incidence by years of follow-up, together with the corresponding 95% CI. Based upon Burn and colleagues (47). Andrew T. Chan et al. Cancer Prev Res 2012;5:164-178 ©2012 by American Association for Cancer Research