Promoter Hypermethylation of the O6-Methylguanine DNA Methyltransferase Gene and Microsatellite Instability in Metastatic Melanoma Maija R.J. Kohonen-Corish,

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Promoter Hypermethylation of the O6-Methylguanine DNA Methyltransferase Gene and Microsatellite Instability in Metastatic Melanoma Maija R.J. Kohonen-Corish, Wendy A. Cooper, Jawad Saab, John F. Thompson, Ronald J.A. Trent, Michael J. Millward Journal of Investigative Dermatology Volume 126, Issue 1, Pages 167-171 (January 2006) DOI: 10.1038/sj.jid.5700005 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Analysis of the dinucleotide repeat D9S161 from two patients with metastatic melanoma (lung) and their matching normal lung tissue. MSI is seen as the presence of extra peaks in the tumor tissue as indicated by arrows. (a) Expected allele 125bp and extra allele in tumor 127bp; (b) expected alleles 125 and 115bp and extra allele 109bp. Journal of Investigative Dermatology 2006 126, 167-171DOI: (10.1038/sj.jid.5700005) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions