(A) Non-isotopic in situ hybridisation of human papillomavirus type 16 (HPV-16). (A) Non-isotopic in situ hybridisation of human papillomavirus type 16.

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(A) Non-isotopic in situ hybridisation of human papillomavirus type 16 (HPV-16). (A) Non-isotopic in situ hybridisation of human papillomavirus type 16 (HPV-16). Integrated HPV signals (arrowheads) according to Cooper’s criteria were demonstrated in the nuclei of the 16Da cells. All the nuclei of the 16Da cells showed positive signals. Original magnification, ×200. (B) An HPV signal was not demonstrated in the control non-HPV transfected DLD-1 cells. Original magnification, ×200. T Kinjo et al. Mol Path 2003;56:97-108 ©2003 by BMJ Publishing Group Ltd and Association of Clinical Pathologists