Proposed model of the tumor-suppressive effects of TPL2 in the lung.

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Proposed model of the tumor-suppressive effects of TPL2 in the lung. Proposed model of the tumor-suppressive effects of TPL2 in the lung. TPL2 contributes to p53 response to DNA damage caused by genotoxic agents or oncogenic stress through JNK-dependent up-regulation of nucleophosmin. Genetic or epigenetic aberrations (e.g., loss of heterozygosity, overexpression of miR-370, or oncogenic RAS signaling) may independently induce TPL2 down-regulation, leading to diminished JNK and p53 responses, reduced cell death, and accelerated carcinogenesis. Katerina Gkirtzimanaki et al. PNAS 2013;110:16:6260-6261 ©2013 by National Academy of Sciences