Can Eph Receptors Stimulate the Mind?

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Can Eph Receptors Stimulate the Mind? Keith K. Murai, Elena B. Pasquale Neuron Volume 33, Issue 2, Pages 159-162 (January 2002) DOI: 10.1016/S0896-6273(02)00565-2

Figure 1 Modulation of Synaptic Function by the EphB2 Receptor In synapses of wild-type mice (left), EphB2 modulates Ca2+ influx through the NMDA receptor via Src family kinases. NMDA receptor currents mediate LTP, LTD, and downstream signaling events leading to changes in gene transcription. EphB2 may also transmit signals that influence gene transcription and actin reorganization independently of NMDA receptors. In synapses from EphB2 knockout mice (right), NMDA receptor-mediated Ca2+ currents are reduced. This reduction, along with decreased signaling downstream of EphB2, impairs LTP, LTD, and transcriptional events. Neuron 2002 33, 159-162DOI: (10.1016/S0896-6273(02)00565-2)