Transcriptome changes in Cnot6l knockout oocytes and zygotes.

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Transcriptome changes in Cnot6l knockout oocytes and zygotes. Transcriptome changes in Cnot6l knockout oocytes and zygotes. (A) Transcriptional landscape in the Cnot6l locus in oocytes from Cnot6l+/− and Cnot6l−/− animals. Shown is a UCSC genome browser snapshot (36) of the Cnot6l locus with expression data from one of the replicates of Cnot6l+/− and Cnot6l−/− samples. The orange region indicates the region deleted in knockouts. (B) Loss of Cnot6l expression has no effect on Cnot6 expression. Shown is a UCSC genome browser snapshot of the Cnot6 locus from the same samples as in panel (A). (C) Principal component analysis of transcriptomes of Cnot6l−/− and control oocytes and zygotes. Heterozygous littermates were used as controls in case of GV and one-cell zygotes; age-matched C57BL/6 females were used as controls for MII eggs because there were not enough Cnot6l+/− littermates for all control samples. (D) Differentially expressed transcripts in Cnot6l−/− GV oocytes, MII eggs, and one-cell zygotes. MA plots depict genes with significantly higher (red) or lower (blue) mRNA abundance. Dashed lines depict twofold change for easier navigation. The outlier gene at the bottom of each graph is Cnot6l.(E) Venn diagrams depicting numbers of genes showing significantly different transcript abundances in Cnot6l−/− oocytes and zygotes. Filip Horvat et al. LSA 2018;1:e201800084 © 2018 Horvat et al.