Nitric oxide mediates fluid accumulation during cardiopulmonary bypass

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Presentation transcript:

Nitric oxide mediates fluid accumulation during cardiopulmonary bypass Kurt E. Wehberg, MDa, Andrew H. Foster, MDb, Robert M. Wise, MSb, Joseph S. McLaughlin, MDb, Martha J. Brunner, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 1, Pages 168-174 (July 1996) DOI: 10.1016/S0022-5223(96)70193-9 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 CPB pump-oxygenator unit provides constant nonpulsatile flow and oxygenation through hollow-fiber membrane. Total volume of extracorporeal circuit is 46 ml. SVC, Superior vena cava; IVC, inferior vena cava. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 168-174DOI: (10.1016/S0022-5223(96)70193-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Fluid accumulation during CPB. Significant differences between control and l-NAME groups (p < 0.01) at specific time points represented by asterisks; significant differences between control and l-arginine (p < 0.01)represented by plus signs. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 168-174DOI: (10.1016/S0022-5223(96)70193-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Percentage weight gain after 3 hours of CPB. Note that weight gain was significantly less with l-arginine (p < 0.05 vs control, represented by plus sign) and greater with l-NAME (p < 0.01 vs control represented by asterisk). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 168-174DOI: (10.1016/S0022-5223(96)70193-9) Copyright © 1996 Mosby, Inc. Terms and Conditions