Optimizing Treatment of Refractory Gout

Overview of Gout

Prevalence of Gout

Gout More Than Podagra

ACR Gout Classification Criteria

Imaging in Gout

Identifying Patients With Severe or Refractory Gout

Characteristics of Severe Gout

Implications of Uncontrolled Gout

Treatment Goals in Gout

ACR Management Guidelines Use of Pharmacologic ULT

ACR/EULAR Treatment Recommendations

Allopurinol

Febuxostat

Pegloticase for Refractory Gout

Pegloticase for Refractory Gout Tophi, Uric Acid Reductions

Pegloticase for Refractory Gout Safety

Limiting Risk for Pegloticase Immunogenicity

Investigational Agents for Refractory Gout

Limiting AEs in the Management of Gout

Concluding Remarks

Abbreviations