Protein Cascades

Cascades Activator Output

Properties of Protein Cycles Build a model of a protein cycle 2 Use simple irreversible mass-action kinetics for the forward and reverse arms. 3. Investigate how the steady state concentration of the phosphorylated protein changes as a function of the forward rate constant.

Cascades

Properties of Protein Cycles 1. Investigate what happens when you use simple irreversible Michaelis-Menten Kinetics. 2. Investigate how the response changes as you decrease the two Kms

Ultrasensitivity

Multiple Protein Cycles forming a Cascade Activator Cascade two cycles together

Exercise Activator Output

Cascades

Cascades 1. Investigate what happens when you use simple irreversible Michaelis-Menten Kinetics. 2. Investigate how the response changes with the two Kms