The Prognostic Importance of Immunohistochemically Detected Node Metastases in Resected Esophageal Adenocarcinoma Tara A. Waterman, BA, Jeffrey A. Hagen,

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The Prognostic Importance of Immunohistochemically Detected Node Metastases in Resected Esophageal Adenocarcinoma Tara A. Waterman, BA, Jeffrey A. Hagen, MD, Jeffrey H. Peters, MD, Steven R. DeMeester, MD, Clive R. Taylor, MD, PhD, Tom R. DeMeester, MD The Annals of Thoracic Surgery Volume 78, Issue 4, Pages 1161-1169 (October 2004) DOI: 10.1016/j.athoracsur.2004.04.045

Fig 1 Photomicrograph of an immunohistochemistry-stained slide showing individual tumor cells within the substance of the lymph node and a morphology consistent with cancer. The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)

Fig 2 Actuarial survival based on the presence or absence of lymph node metastases by hematoxylin & eosin examination (χ2 = 8.44; p = 0.004). The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)

Fig 3 Actuarial survival based on the extent of lymph node involvement, classified by the number of involved nodes (A) and the lymph node ratio (B) by hematoxylin & eosin (H&E) examination (χ2 = 30.8; p < 0.0001 and χ2 = 24.5; p < 0.0001, respectively). The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)

Fig 4 Actuarial survival based on the presence or absence of lymph node metastases by immunohistochemistry (IHC) examination (χ2 = 0.48; p = 0.49). The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)

Fig 5 Actuarial survival in patients with limited lymph node involvement by hematoxylin & eosin (H&E) examination (ratio of involved nodes, < 10%) for patients with a combined node ratio of less than 10% and for a combined node ratio more than 10% (χ2 = 4.66; p = 0.03). (IHC = immunohistochemistry.) The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)

Fig 6 Actuarial survival according to a proposed classification scheme based on hematoxylin & eosin (H&E) and immunohistochemistry (IHC) examination (χ2 = 27.3; p < 0.0001). The Annals of Thoracic Surgery 2004 78, 1161-1169DOI: (10.1016/j.athoracsur.2004.04.045)