Alexander S. Tretinyak, MD, Eugene S. Lee, MD, Kristina M

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Supplemental oxygen reduces intimal hyperplasia after intraarterial stenting in the rabbit Alexander S. Tretinyak, MD, Eugene S. Lee, MD, Kristina M. Uema, Alexandre C. d'Audiffret, MD, Michael P. Caldwell, BS, Steven M. Santilli, MD, PhD Journal of Vascular Surgery Volume 35, Issue 5, Pages 982-987 (May 2002) DOI: 10.1067/mva.2002.123090 Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Transarterial wall oxygen gradient for stented and nonstented normoxic day-0 rabbits (mean ± standard deviation). Measured partial pressure of oxygen (PO2) is significantly lower in stented rabbits in outer 70% of artery wall. Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Transarterial wall oxygen gradient for intraarterial stent day-0 rabbits, control versus oxygen-supplemented (mean ± standard deviation), with all values significantly different (P <.001). PO2, Partial pressure of oxygen. Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Transarterial wall oxygen gradients for intraarterial stent day-7 and day-28 rabbits for control versus oxygen-supplemented (mean ± standard deviation), with all supplemented values significantly higher than control values (P <.001). PO2, Partial pressure of oxygen. Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Cellular proliferation as measured with ratio of cells with positive staining results for BrdU to total cell count of intima and media for 14-day control and oxygen-supplemented rabbits (P <.001). Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 5 Cellular proliferation 1-mm distal to stent in 14-day control rabbit. Immunoperoxidase staining of BrdU-labeled cells. Darkly stained nuclei (arrows) represent cells with positive staining results. IEL, Internal elastic lamina (biotinylated mouse anti-BrdU; original magnification, ×200). Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 6 Cellular proliferation 1-mm distal to stent in 14-day oxygen-supplemented rabbit. Immunoperoxidase staining of BrdU-labeled cells. Darkly stained nuclei (arrows) represent cells with positive staining results. IEL, Internal elastic lamina (biotinylated mouse anti-BrdU; original magnification, ×200). Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 7 Cellular proliferation as measured with ratio of cells with positive staining results for BrdU cells to total cell count of intima and media for 28-day control and oxygen-supplemented rabbits (P <.025). Journal of Vascular Surgery 2002 35, 982-987DOI: (10.1067/mva.2002.123090) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions