The effects of KY19382 on growth plate senescence and longitudinal bone growth. The effects of KY19382 on growth plate senescence and longitudinal bone.

Slides:

Advertisements

Similar presentations

Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.

Advertisements

SCC244 significantly inhibited c-Met–driven tumor growth in cancer CDX models. SCC244 significantly inhibited c-Met–driven tumor growth in cancer CDX models.

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Quantitative assessment of articular cartilage and subchondral bone histology in the meniscectomized guinea pig model of osteoarthritis P Pastoureau,

Yingben Xue, James C. Fleet Gastroenterology

Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays. Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays.

Inflammasome responses.

Volume 137, Issue 3, Pages (September 2009)

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Guy Trudel, MD, MSc, Susan H. Kilborn, DVM, DVSc, Hans K. Uhthoff, MD

Fig. 8. In vivo suppression of MM by CMLD

BV6 increases tumor burden in bone.

Smaller T cell zone FRC areas in aged spleens.

Functional interaction of Eμ-Tcl1 tumor cells with FDC networks.

M.M.-G. Sun, F. Beier Osteoarthritis and Cartilage

T. Kimura, T. Ozaki, K. Fujita, A. Yamashita, M. Morioka, K. Ozono, N

CCL21 localizes to T cell zone FRCs in young and aged spleens.

Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding, or TPA. Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding,

GM-CSF–producing γδT cells are involved in the development of EAM

Fig. 5 Local gel scaffold for T cell memory response.

Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor H. Tanoue, J. Morinaga, T. Yoshizawa,

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

Knockdown of DAO inhibits DNA damage–induced senescence.

Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

BDNF expression in the cerebellum and brain stem region.

Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.

CAIA is attenuated in Nrdc – / – mice.

Animal cohort used for recording visually evoked neuronal responses.

Distribution of splenic T cells, B cells, and NK cells in NSG hL-7xhIL-15 humanized mice. Distribution of splenic T cells, B cells, and NK cells in NSG.

The effects of KY19382 on chondrocyte proliferation and differentiation. The effects of KY19382 on chondrocyte proliferation and differentiation. (A) ATDC5.

DDR1 plays an intrinsic role in primary epithelial cells undergoing branching morphogenesis and is required for correct organization of the basement membrane.

Ectopic expression of wt-DAO, but not the inactive mutant, promotes senescence. Ectopic expression of wt-DAO, but not the inactive mutant, promotes senescence.

Defects in neuronal cell migration from the SVZ

Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and increased T-cell activation. Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and.

ONC201 activates the ISR. ONC201 activates the ISR. (A) Western blotting analysis for ATF4, CHOP, ATF3, and TRB3 on lysates from HCT116 cells cultured.

Socs1 KD tumors exhibit a more T cell–inflamed phenotype and increased CD8+ T cell activation. Socs1 KD tumors exhibit a more T cell–inflamed phenotype.

Histological analyses for limb-specific Uhrf1 KO mice.

T1D is reduced in CT-treated NOD mice.

Histology of Brucella bone marrow foci in mice.

Chop deletion preserves β-cell function in P58IPK−/− mice.

Hepatocyte Growth Factor Regulates the miR-206-HDAC4 Cascade to Control Neurogenic Muscle Atrophy following Surgical Denervation in Mice Wooshik Choi,

Temporal origins of h-ChCs labeled in Cdh6-CreER;Dlx5/6-Flp;Ai65 mice.

MMP expression at the growth plate.

Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal tumors. Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal.

Diaphanous is required presynaptically for normal synaptic growth.

PTZ-induced neuronal activity visualized by IEGs

Fig. 5. Inhibition of osteoclastic activity in the tibial epiphyseal plate by Rhus verniciflua Stokes (RVS) treatment in ovariectomy-induced osteoporotic.

CD11c+ DCs from NOD.hCD205 mice are able to process and present Ag to diabetogenic CD8+ T cells. CD11c+ DCs from NOD.hCD205 mice are able to process and.

The SFKs confer BRAF inhibitor resistance in BRAF-mutant melanoma cells. The SFKs confer BRAF inhibitor resistance in BRAF-mutant melanoma cells. A, phospho-protein.

Dose-dependent effect of IP6 feeding on molecules associated with tumor sustenance and glucose transportation in dorsolateral prostate of TRAMP mice. Dose-dependent.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. A, 4T1/HAS3.

Representative macrophage staining images only from the knee joints of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.

Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth and metastasis. Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth.

NT157 treatment inhibits LNCaP xenograft growth and delays castration-resistant progression. NT157 treatment inhibits LNCaP xenograft growth and delays.

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.

RUNX3 depletion induces cellular senescence in an ATM/ATR dependent, but p53-independent manner. RUNX3 depletion induces cellular senescence in an ATM/ATR.

The effect of a DIO regimen ± EPA+DHA supplementation on tumor growth.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC xenografts. Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC.

GCS-100 selectively kills KRAS-addicted lung tumors.

Transgenic mice with constitutively active NIK show increased tumor growth in bone. Transgenic mice with constitutively active NIK show increased tumor.

BV6 increases bone metastasis.

In vivo effect of KIN-193 on PTEN-deficient tumors.

BH3-targeted inhibitors drive specific resistance in human cell lines, which can be overcome with alternating or combining inhibitors. BH3-targeted inhibitors.

Fig. 3 Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. Minimal treatment.

Fig. 5 Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. Effects of in vivo blockade of TLR9 on adipose.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

Presentation transcript:

The effects of KY19382 on growth plate senescence and longitudinal bone growth. The effects of KY19382 on growth plate senescence and longitudinal bone growth. (A–I) KY19382 (0.1 mg/kg) was administered to 7-wk-old mice (A–E) or 3-wk-old mice (F–I) by daily intraperitoneal injection for 2 wk (n = 7). H&E staining, IHC analyses with the indicated antibodies, and TRAP staining in the growth plates of proximal tibiae treated with KY19382 (A, F). Quantitative analyses of the cell number per column (mean ± SEM, n = 7; t test, ***P < 0.0005) (B) or the height (mean ± SEM, n = 7; t test, ***P < 0.0005) (G) of resting zone and proliferative zone (RZ&PZ) and hypertrophic zone (HZ) in the growth plates of proximal tibiae. Quantitative analyses of BrdU-positive cells in the growth plates (mean ± SEM, n = 5; t test, ***P < 0.0005) (C, H). Quantitative analyses of the number of TRAP-positive foci along 250 μm of the cartilage/bone interface (mean ± SEM, n = 3; t test, *P < 0.05) (D, I). Immunoblot analyses with the indicated antibodies in the growth plate of proximal tibiae of mice treated with KY19382 (E). Scale bars, 50 μm. (J) 3-wk-old mice were intraperitoneally injected with KY19382 (0.1 mg/kg) daily for 10 wk. Representative radiographs are shown (left), and tibial length was measured (right) (mean ± SEM, n = 7–15; t test, ***P < 0.0005). The area within the dashed lines indicates the growth plate zone. n.s., no significance; TRAP, tartrate-resistant acid phosphatase. Sehee Choi et al. LSA 2019;2:e201800254 © 2019 Choi et al.