Ag 85A–specific immune responses.

Slides:

Advertisements

Similar presentations

Volume 5, Issue 1, Pages (January 2009)

Advertisements

Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

Expansion and isolation of NY-ESO-1–specific T cell clones.

Volume 25, Issue 2, Pages (February 2017)

Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells by Christian P. Kalberer, Uwe Siegler, and Aleksandra Wodnar-Filipowicz.

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection Vladimir P. Badovinac,

Hans-Peter Raué, Carol Beadling, Jennifer Haun, Mark K. Slifka

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

LP-BM5–induced increases of cytokine levels in the hind paw skin of B6 mice. LP-BM5–induced increases of cytokine levels in the hind paw skin of B6 mice.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Volume 29, Issue 2, Pages (August 2008)

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.

Exogenous IL-4 cannot rescue Th2 cytokine expression in HuR-deficient cells. Exogenous IL-4 cannot rescue Th2 cytokine expression in HuR-deficient cells.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Altered cytokine production by Klrk1−/− NOD CTL

The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed by Jelena Popović, Liang-Ping Li, Peter Michael Kloetzel,

Confirmation of novel RSV CD8+ T cell epitopes.

Tetramer staining performed to determine frequencies of epitope-specific T cells after clearance of HPV16 infection but prior to isolation of T-cell clones.

IL-33 treatment improves restorative macrophages (MΦ) but not function

A predominant Th1 type of immune response is induced early during acute Helicobacter pylori infection in rhesus macaques Joseph J. Mattapallil, Satya.

IFN-γ induces TNF family ligand protein expression in vitro and in vivo. IFN-γ induces TNF family ligand protein expression in vitro and in vivo. (A and.

Immunopathology in RSV Infection Is Mediated by a Discrete Oligoclonal Subset of Antigen-Specific CD4+ T Cells Steven M Varga, Xiaoting Wang, Raymond.

Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily.

RSV peptide library screen for candidate CD4+ T cell epitopes.

Volume 5, Issue 1, Pages (January 2009)

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Volume 32, Issue 1, Pages (January 2010)

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Volume 41, Issue 1, Pages (July 2014)

Identification of mouse AAV capsid-specific CD8+ T cell epitopes

Volume 44, Issue 5, Pages (May 2016)

Virus-specific T cell responses are detected in all MERS survivors.

Volume 16, Issue 4, Pages (April 2002)

Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection

MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

T-bethi MP cells produce IFN-γ in response to IL-12.

Figure 4 Increased susceptibility of MIF−/− CD4+ T cells to immunosuppression by Dex in EAE (A) MOG35-55 peptide-activated donor cells from wild-type (Wt)

Volume 35, Issue 4, Pages (October 2011)

Volume 38, Issue 2, Pages (February 2013)

IFN-γ–producing cells in the spleen and lungs postimmunization.

Antigen-specific immune responses are enhanced in hypertension.

APCs from hypertensive mice present antigens more efficiently.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

LG NK cells appear to be conventional in phenotype.

CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.

Induction of IL-3–secreting CD4+ T cells.

Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.

CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without.

MK-8628 restricts cytokine production in T lymphocytes.

CypD-deficient mice are susceptible to Mtb infection.

Gab3 is required for IL-2– and IL-15–induced priming and expansion of NK cells. Gab3 is required for IL-2– and IL-15–induced priming and expansion of NK.

Vaginal CD11c+ DCs from IL-17A−/− mice are impaired in potentiating Th17 responses because of diminished IL-1β production. Vaginal CD11c+ DCs from IL-17A−/−

Figure 3. Enhancement of cytokine production by CD8+ T cells at TT

Immunization regimens that include a GLA-SE-formulated protein vaccine generate memory CD4 T cells. Immunization regimens that include a GLA-SE-formulated.

CD25 expression predicts effector and memory differentiation.

Treg expression of Gata3 plays a major role in controlling dermal fibrosis. Treg expression of Gata3 plays a major role in controlling dermal fibrosis.

MDSC-derived IL-6 enhances tumor progression through the inhibition of tumor-specific TH1 development and of their helper activity for CD8+ T cells. MDSC-derived.

Local proliferation of infiltrating circulating memory T cells.

Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary.

Moderate-affinity vaccine antigens elicited greatest antitumor response. Moderate-affinity vaccine antigens elicited greatest antitumor response. Wild-type.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.

E2 induces IL-17–producing γδ+ T cells in the FGT

Meningeal γδ T cells are biased toward IL-17 production.

Phenotyping of T cells. Phenotyping of T cells. Circulating lymphocytes from a tumor-naïve C57BL/6 mice (left column) were compared with those from C57BL/6.

Volume 25, Issue 2, Pages (February 2017)

Presentation transcript:

Ag 85A–specific immune responses. Ag 85A–specific immune responses. (A) Mice were infected with eMCMV or MCMV85A and 4 wk later boosted with 2 × 109 virus particles Ad85A i.m. Six days later, lung, spleen, and liver cells were isolated and stimulated for 6 h with pooled 85A peptides. (B) Spleen cells from eMCMV- or MCMV85A-infected mice were stimulated in vitro with a pool of 15-mer peptides covering the sequence of Ag 85A, expanded with IL-2, rested, and restimulated with 85A peptides before assaying by intracellular staining and flow cytometry for Ag-specific IFN-γ–producing cells. (C) Lung or spleen cells from MCMV85A-infected mice boosted with Ad85A were stimulated with individual 85A peptides covering the dominant H-2d CD4 and CD8 epitopes. The frequencies of IFN-γ– or IL-2–producing cells were determined by flow cytometry on CD8- and CD4-gated cells. Results are expressed as the means ± SD of three or four mice per group, representative of two independent experiments. Data were analyzed by a one-way ANOVA with a Tukey posttest. Peter C. L. Beverley et al. J Immunol 2014;193:2306-2316 Copyright © 2014 The Authors