Cross Coupling Reaction

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Presentation transcript:

Cross Coupling Reaction 1) Stille Reaction 2) Suzuki Reaction 3) Sonogashira Reaction

Carbonylative Cross Coupling Reaction

1) Stille coupling 반응

Intramolecular Stille Reaction

Recycle of Sn

2) Suzuki coupling Reaction

Intramolecular Suzuki Reaction

Synthesis of Bombyokol Aromatic boronic acid

Unreactive Compounds Reactivity of Halide: vinyl iodide, vinyl bromide》aryl iodide > vinylchloride 》aryl bromide, Reactivity of Catalysts: PdCl2(PPh3)2, Pd(PPh3)4, Pd(OAc)2, PdCl2

3) Sonogashira coupling

Anticancer nucloside Metal acetylide: Sn, Zn, Mg

Wacker Process

Historically, in 1894 Phillips reported that acetaldehyde and Pd(0) was isolated from ethylene gas and aqueous PdCl2. This was further developed by using CuCl2 and O2.