Metascape Tripathi et al 2015pathways enrichment analysis (Tripathi et al 2015, http://metascape.org) of differentially expressed genes (counts > 5, FC.

Slides:



Advertisements
Similar presentations
RNA-seq analysis of iWAT and eWAT.
Advertisements

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.
(A) ZR75-1 cells were treated with 1 μM 5-aza-2′-deoxycytidine (5-Aza) for 4 d. (A) ZR75-1 cells were treated with 1 μM 5-aza-2′-deoxycytidine (5-Aza)
PPARγ signaling correlates with LATS2 in human and mouse tumors and promotes cell death in a LATS2-dependent manner. PPARγ signaling correlates with LATS2.
Comparison of N. gonorrhoeae gene expression during infection in men and women in vivo. Comparison of N. gonorrhoeae gene expression during infection in.
Analysis of total and polysomal RNA clk-1(qm30) and clk-1(qm30)+WT.
LATS2 is a tumor suppressor in a mouse lumB breast cancer model.
(A) Schematic representation of the conditional Lats1 locus.
B7-H4 expression correlates with MHC-I expression and improved prognosis in patients with breast cancer. B7-H4 expression correlates with MHC-I expression.
Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT tumors. Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT.
LATS2 promotes death of lumB cells.
JNK signature in breast cancer cells is linked to ECM, stem cell, and wound healing gene networks and is enriched in basal‐like breast cancer JNK signature.
Volume 47, Issue 5, Pages e4 (November 2017)
Meta-analysis of the Listeriomics transcriptomic data sets.
Correlation of mouse gene expression with bacterial gene expression.
Heatmaps of differential OTUs
Individual genes exhibit distinct female-enriched expression patterns.
(A) Genotyping of the Lats2 and Cre alleles in the PyMT-derived cell lines (see primers location in Fig S2A). (A) Genotyping of the Lats2 and Cre alleles.
Quantitative RT-PCR results of relative gene expression normalized to wild-type (WT) expression levels for the LjMYB14 transgene (A) and genes specific.
Down-regulation of LATS1 promotes the formation of tumors enriched in basal-like features. Down-regulation of LATS1 promotes the formation of tumors enriched.
Clusters from the functional network
Hironori Hara et al. BTS 2018;3:
Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.
The relationship between the genes in mice and human samples
Intestinal differentiation is coupled with global rewiring of gene expression Intestinal differentiation is coupled with global rewiring of gene expression.
(A) Example time series for data and simulation.
Treatment with DM-α-KG rescues gene expression in the context of chronic mtDNA depletion. Treatment with DM-α-KG rescues gene expression in the context.
MAGs and testes transcript expression levels in the An. gambiae complex. MAGs and testes transcript expression levels in the An. gambiae complex. (A) Percentage.
FACT correlates with active gene expression.
Expression profiles of 5,493 transcripts grouped by k-means clustering
Analysis of the nonsynonymous to synonymous substitutions dN/dS (ω) for the 5,493 1:1 ortholog transcripts. Analysis of the nonsynonymous to synonymous.
CiCo relation to linear transcripts.
LATS2-associated gene expression pattern is down-regulated specifically in lumB breast tumors. LATS2-associated gene expression pattern is down-regulated.
(A) Schematic representation of the conditional Lats2 locus.
LLC cells exhibit a blunted response to IFNγ in vitro and in vivo compared with CMT167. LLC cells exhibit a blunted response to IFNγ in vitro and in vivo.
Statistics of cleavage sites and mutant-enriched sites.
(A) Distribution of LATS2 mRNA expression levels in different breast cancer subtypes (PAM50, METABTIC dataset); ***P-value < 0.001, t test comparing lumB.
Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.
RNAseq–Volcano plots, qPCR validation, and GO enrichment analysis.
Genetic maintenance of histone acetylation prevents gene expression changes in the promoters of genes responding to acute mtDNA depletion. Genetic maintenance.
Phospho-proteomic analysis of acutely and chronically stimulated PDGFRα signaling. Phospho-proteomic analysis of acutely and chronically stimulated PDGFRα.
Analysis of renal transcriptome responses identifies LX-regulated transcriptional networks. Analysis of renal transcriptome responses identifies LX-regulated.
Gene expression signature of NK cells in NSG hL-7xhIL-15 humanized mice. Gene expression signature of NK cells in NSG hL-7xhIL-15 humanized mice. RNA sequencing.
Identification of acetylated peptides and proteins by LC-MS/MS.
Heatmaps reveal significantly affected pathways by 4 mg/liter polymyxin B (PMB) in strains PAK and PAKpmrB6 at 1 h using transcriptomics. Heatmaps reveal.
Stage-specific expression modules of preimplantation development.
Extended analysis of differential expression datasets.
Cross-species analysis of maternal gene transcripts.
Enrichment of miRNAs among DPAR genes and their relative expression under dietary restriction. Enrichment of miRNAs among DPAR genes and their relative.
(A) Relative expression levels of the top most down-regulated genes in LATS2L breast tumors (TCGA-BRCA dataset, see Fig 1) in the panel of breast cancer.
LATS2 augments oxidative phosphorylation.
Fig. 5 Transcriptional changes in dKO mice after HFD regimen.
Fig. 2 Inflammatory pathways with STAT1 as a key regulator are enriched in ICB responsive tumors in mouse models and patients. Inflammatory pathways with.
Distinct molecular and clinical correlates of H3F3A mutation subgroups
KEGG categories of host DEGs (up- and downregulated genes) enriched at selected points after φAbp1 infection. KEGG categories of host DEGs (up- and downregulated.
The log-transformed reporter Z scores of the metabolic pathways showing significant differences between the PCOS and control groups. The log-transformed.
Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell.
Fig. 3 Transcriptional changes in dKO mice.
EN1-associated chromatin complexes in breast cancer cells.
CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,
Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and.
Expression of 20 genes significantly associated with reduced survivability in GBM is shown across 33 TCGA diseases. Expression of 20 genes significantly.
Γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. γ-TmT reduces serum E2 levels and induces estrogen-metabolizing.
Identification of general and tissue-specific essential genes.
Identification of putative TET1 targets in TNBC
KRAS-mutant lung adenocarcinoma subsets exhibit distinct patterns of immune system engagement. KRAS-mutant lung adenocarcinoma subsets exhibit distinct.
Fig. 3. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR
Transcriptomic Analysis of GmSIN1 OE-1 Transgenic Soybean.
DNSP16 mutant MERS-CoV infection produces minimal changes in early host responses. dNSP16 mutant MERS-CoV infection produces minimal changes in early host.
Pathway-based analysis of the differentially expressed proteins in colonic mucosa. Pathway-based analysis of the differentially expressed proteins in colonic.
Presentation transcript:

Metascape Tripathi et al 2015pathways enrichment analysis (Tripathi et al 2015, http://metascape.org) of differentially expressed genes (counts > 5, FC > 1.5, adjP-value < 0.05) in Lats2-CKO mammary tumors (PyMT) or Lats2-CKO livers, relative to their WT littermate controls. Metascape Tripathi et al 2015pathways enrichment analysis (Tripathi et al 2015, http://metascape.org) of differentially expressed genes (counts > 5, FC > 1.5, adjP-value < 0.05) in Lats2-CKO mammary tumors (PyMT) or Lats2-CKO livers, relative to their WT littermate controls. Heatmap shows the enrichment score (−log10(P-value)) for each pathway in each of the differentially expressed gene lists. Noa Furth et al. LSA 2018;1:e201800171 © 2018 Furth et al.