BAK oligomerization in cells treated by UV is

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Apoptosis By Douglas R. Green

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Presentation transcript:

BAK oligomerization in cells treated by UV is Cell death independent Caspase independent Cytochrome c release independent Caspase-2 independent All of above

How did the authors identify Mcl-1 Biochemical purification By guessing By both biochemical purification and candidate testing By genetic cloning None of above

Mcl-1 elimination upon UV irradiation is due to Blocking of protein synthesis Accelerated protein degradation Both blocking of protein synthesis and accelerated protein degradation An unknown reason None of above

Overexpression of Bcl-xL can A. Inhibit UV-induced Bax translocation to mitochondria B. Inhibit UV-induced Mcl-1 degradation C. Inhibit UV-induced Bax oligomerization on mitochondria D. Inhibit UV-induced Bak translocation to mitochondria D. None of the above

Based on the paper, the role of Bcl-xL in UV-induced apoptosis is A. to promote Mcl-1 degradation B. to help translocation of Bax to mitochondria C. to mediate Bax oligomerization on mitochondria D. not understood E. to mediate cytochrome c release