Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Jeffrey M.

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Presentation transcript:

Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Jeffrey M Pearl, MD, Peter B Manning, MD, Jerri L McNamara, M.Michelle Saucier, BS, Donald W Thomas The Annals of Thoracic Surgery Volume 68, Issue 4, Pages 1369-1375 (October 1999) DOI: 10.1016/S0003-4975(99)00978-9

Fig 1 The mean end-CPB TXB2 level decreased from 101.2 ± 34 pg/mL at end-CPB to 46.9 ± 31 pg/mL after MUF (p < 0.05). Despite this decrease in TXB2 occurring during MUF, levels 1 hour postbypass were nearly identical to values in the non-MUF group. The Annals of Thoracic Surgery 1999 68, 1369-1375DOI: (10.1016/S0003-4975(99)00978-9)

Fig 2 Levels of LTB4 increased significantly during CPB in both groups. After MUF, levels increased to 119% of pre-MUF values. After CPB, levels of LTB4 fell towards baseline in both groups. The Annals of Thoracic Surgery 1999 68, 1369-1375DOI: (10.1016/S0003-4975(99)00978-9)

Fig 3 ET-1 increased in a progressive manner during bypass. ET-1 levels continued to rise 1 hour post-CPB, and were unaffected by MUF. The Annals of Thoracic Surgery 1999 68, 1369-1375DOI: (10.1016/S0003-4975(99)00978-9)