Cryptic No Longer: Arrays of CLASP1 TOG Domains

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Presentation transcript:

Cryptic No Longer: Arrays of CLASP1 TOG Domains Jeremy D. Wilbur, Rebecca Heald Structure Volume 21, Issue 6, Pages 869-870 (June 2013) DOI: 10.1016/j.str.2013.05.002 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 CLASP TOG Domain 2 Architecture May Confer Unique Activity to CLASPs Compared to Other TOG Domain-Containing Proteins (A) TOG or cryptic TOG (TOG-like [TOGL]) domains found in human CLASP1. (B) TOG2 adopts a bent architecture and is stabilized by an N-terminal helix (α2N). (C) TOG2 may stabilize the depolymerizing MT by binding curved tubulin dimers in curling protofilaments. Structure 2013 21, 869-870DOI: (10.1016/j.str.2013.05.002) Copyright © 2013 Elsevier Ltd Terms and Conditions