Structure and receptor-binding properties of SCH-C.

Slides:

Advertisements

Similar presentations

Plot 1: Estimate of Kd for oxidized FAD binding to NSMOA in the presence of saturating benzene. Solutions containing 50 µM oxidized FAD and benzene concentrations.

Advertisements

Anesthes. 1998;88(3): Figure Legend:

Affinity and Avidity by: Omar Ammar

Receptor Theory & Toxicant-Receptor Interactions

Figure 1. Serum concentrations of IGF-I (A), IGF-II (B), IGFBP-3 (C), and ALS (D) throughout life in GHD (closed circles) and healthy control (open circles)

The stimulatory effect of Taxol, epoB, and Disco on tubulin polymerization correlates well with their inhibitory effect on photolabeling of β-tubulin.

Identification and characterization of the ta2-1 mutant.

SPR characterization of the specific interaction between AuNP–Pep1 and HEWL. (A) Binding of AuNPs functionalized with 20 Pep1 and different numbers of.

Balancing selection characterizes both MAE genes and cell type-specific genes (expressed in either nsc or asl but not in both). Balancing selection characterizes.

Masahiro Ueda, Tatsuo Shibata Biophysical Journal

(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.

Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.

CatL activity levels and expression of the DC forms of CatB and CatL are reduced in the α5β1-negative CHO cells. CatL activity levels and expression of.

Behaviorally dependent allele-specific expression.

Lymphoma cells with BCL2/PMAIP1 coamplification are highly sensitive to BCL-2 inhibitor. Lymphoma cells with BCL2/PMAIP1 coamplification are highly sensitive.

ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. ERVmap reveals additional breast cancer-associated ERVs.

PMAIP1/NOXA gene amplification increases DLBCL vulnerability to BCL2 inhibitors. PMAIP1/NOXA gene amplification increases DLBCL vulnerability to BCL2 inhibitors.

Cell-type–specific ERV expression in primary cells.

C206, T107, and R278 are the crucial residues for H2O2 catalysis.

Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses by Ruth A. Ettinger,

The interaction of FAM49B and Rac.

Patients with SLE have elevated ERV expression.

A model for dual inhibition of BCL2 and MCL1 to release BIM and induce apoptosis. A model for dual inhibition of BCL2 and MCL1 to release BIM and induce.

P110-free p85 is recruited to PDGFRs with higher affinity than the p85-p110 dimers at low levels of receptor activation. p110-free p85 is recruited to.

DHEA(S) and Allo protected rat chromaffin cells in culture against serum deprivation-induced apoptosis. DHEA(S) and Allo protected rat chromaffin cells.

Parameters to be calculated

Competition binding assays.

(A) NK cell cytotoxicity assays against K562, H9, and Raji target cell lines in the presence (black) and absence (white) of an anti-NKp30 antibody, clone.

Transcriptional response to mating in whole A. gambiae females.

Phosphatase activity associated with Themis and Shp1 in response to different affinity peptide ligands. Phosphatase activity associated with Themis and.

Phosphatase activity associated with Shp1 is reduced in Themis−/− thymocytes. Phosphatase activity associated with Shp1 is reduced in Themis−/− thymocytes.

Variability in protein concentration of urine over a 10-d collection from a single healthy volunteer. Variability in protein concentration of urine over.

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2 by Zil E. Huma, Julie Sanchez,

Submitochondrial localization of mitofilin using quantitative immunoelectron microscopy. Submitochondrial localization of mitofilin using quantitative.

Autoradiographic mapping and characterization of insulin-like growth factor-I receptor binding in human greater saphenous vein Anton N. Sidawy, MD, Fares.

PDGFRα GBM primary cultures demonstrate titratable and temporal DOX-inducible expression of hPDGF-A and receptor activation. PDGFRα GBM primary cultures.

Volume 58, Issue 4, Pages (October 2000)

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

Effect of agonists on receptor mobility.

ICSBP stimulates GAS reporter activity in JAK/STAT-pathway-deficient cells. 2fTGH, U3A, U4A, and γ1A cells were cotransfected with the WT GAS reporter.

Figure 1 Schematic overview of flow cytometry Schematic overview on the analysis of peripheral immune cells by flow cytometry. Schematic overview of flow.

Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes L.J. Raggatt, Ph.D., S.C. Jefcoat, M.S., I. Choudhury, Ph.D., S.

Expression of SYCE2 inhibits the interaction of HP1α with H3K9me3.

Volume 59, Issue 5, Pages (May 2001)

A trans-activating RdRp is required for cRNP activity.

Androgen receptor alterations and outcome.

CCR4 antagonists amplify immunogenicity of vaccines in vivo.

Activation of PKR by the PBM decoy peptide.

Accumulation of asialoglycoproteins, agalactoglycoproteins, and Man-terminated N-glycans during blood protein aging. Accumulation of asialoglycoproteins,

TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. (A.

Effect of pH and bicarbonate (HCO3) vs

Isolates from the NZ97/192 household interact differently with host respiratory epithelial 16HBE cells. Isolates from the NZ97/192 household interact differently.

Plot of BOUND against FREE ligand

Volume 55, Issue 4, Pages (April 1999)

Phillip D. Holler, David M. Kranz Immunity

Increased TCR Avidity after T Cell Activation

Figure 2 Cell-based assay demonstrating differential binding of AChR antibodies to the adult and fetal receptorsThe fetal (gamma subunit specific) and.

Fluorescence assays of diameter dependent cellular toxicity.

Expression of selected genes in the ΔSMcomS strain in response to increasing concentrations of XIP. RT-PCR analysis of gene expression was performed in.

Fluorescence intensity after photobleaching data.

Empty Site Forms of the SRP54 and SRα GTPases Mediate Targeting of Ribosome– Nascent Chain Complexes to the Endoplasmic Reticulum Peter J Rapiejko, Reid.

Suppression of melanoma cell proliferation in response to kinase inhibitors. Suppression of melanoma cell proliferation in response to kinase inhibitors.

CD91- and LOX-1-dependence of presentation of gp96-chaperoned peptides by MHC II. Presentation of gp96-chaperoned peptides by immature bone marrow-derived.

Efficient and preferential pairing of cysteine-modified TCRs

One-photon characterization of RVF5 in neurons.

Effect of bevacizumab on the proliferation of A2780 cells.

NVP-BGJ398 inhibits proliferation of a subset of cancer cell lines.

GBM 112 and GBM 144 cells infected in vitro with HCMV resist growth inhibition by temozolomide. GBM 112 and GBM 144 cells infected in vitro with HCMV resist.

Immunization with IR or F/T 4T1-OVA cells elicits similar numbers of APCs capable of cross-presenting antigen. Immunization with IR or F/T 4T1-OVA cells.

Presentation transcript:

Structure and receptor-binding properties of SCH-C. Structure and receptor-binding properties of SCH-C. (A) The structure of SCH-C. (B) SCH-C inhibits RANTES binding to CCR5. SCH-C was titrated over the concentration range indicated in the presence of [125I]RANTES, and the binding of RANTES to human CCR5 expressed on CHO-cell membranes was measured (■). (C) SCH-C binds with high affinity to CCR5. [3H]SCH-C was titrated over the concentration range indicated; the amount bound to human CCR5 on B550 cells was measured, and the Bmax and KD values were calculated from the Scatchard plot (Inset). The value of each assay point is an average of triplicates (●). Julie M. Strizki et al. PNAS 2001;98:22:12718-12723 ©2001 by National Academy of Sciences