Mark Granada, MD, Jemma B. Wilk, DSc, Marina Tuzova, MD, PhD, David P

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Presentation transcript:

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study Mark Granada, MD, Jemma B. Wilk, DSc, Marina Tuzova, MD, PhD, David P. Strachan, MD, Stephan Weidinger, MD, Eva Albrecht, MSc, Christian Gieger, PhD, Joachim Heinrich, PhD, Blanca E. Himes, PhD, Gary M. Hunninghake, MD, MPH, Juan C. Celedón, MD, DrPH, Scott T. Weiss, MD, William W. Cruikshank, PhD, Lindsay A. Farrer, PhD, David M. Center, MD, George T. O'Connor, MD, MS Journal of Allergy and Clinical Immunology Volume 129, Issue 3, Pages 840-845.e21 (March 2012) DOI: 10.1016/j.jaci.2011.09.029 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Genome-wide association results for imputed SNPs and plasma total IgE concentrations in the FHS cohort. Coordinates on the x-axis represent chromosomes. Negative logarithmic P values are shown on the y-axis. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Quantile-quantile plot of log total IgE concentration GWAS results in the FHS cohort. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Association plot for SNPs in the FCER1A region in the FHS cohort. Negative log-transformed P values are on the left y-axis, and the recombination rate is on the right y-axis. The r2 color scheme for SNPs based on the color gradient key is in the upper right corner of the figure. Only SNPs with P values of less than 10−3 are shown. cM/Mb, Centimorgans per megabase. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Association plot for SNPs in the STAT6 region in the FHS cohort. Negative log-transformed P values are on the left y-axis, and the recombination rate is on the right y-axis. The r2 color scheme for SNPs based on the color gradient key is in the upper right corner of the figure. Only SNPs with P values of less than 10−3 are shown. cM/Mb, Centimorgans per megabase. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Association plot for SNPs in the IL13 region in the FHS cohort. Negative log-transformed P values are on the left y-axis, and the recombination rate is on the right y-axis. The r2 color scheme for SNPs based on the color gradient key is in the upper right corner of the figure. Only SNPs with P values of less than 10−3 are shown. cM/Mb, Centimorgans per megabase. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Association plot for SNPs in the HLA-A and HLA-G region in the FHS cohort. Negative log-transformed P values are on the left y-axis, and the recombination rate is on the right y-axis. The r2 color scheme for SNPs based on the color gradient key is in the upper right corner of the figure. Only SNPs with P values of less than 10−3 are shown. cM/Mb, Centimorgans per megabase. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Association plot for SNPs in the HLA-DQA2 region in the FHS cohort. Negative log-transformed P values are on the left y-axis, and the recombination rate is on the right y-axis. The r2 color scheme for SNPs based on the color gradient key is in the upper right corner of the figure. Only SNPs with P values of less than 10−3 are shown. cM/Mb, Centimorgans per megabase. Journal of Allergy and Clinical Immunology 2012 129, 840-845.e21DOI: (10.1016/j.jaci.2011.09.029) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions