Chromatin shearing is not affected between the two fixation methods. Chromatin shearing is not affected between the two fixation methods. (A) Agarose gel electrophoresis (2%) for MCF-7 (left) and LNCaP (right). Between FA only and FA combined with DSG (FA+DSG), no clear differences in DNA fragment size were observed. (B) Bioanalyzerblots for a breast cancer and a prostate cancer sample. FA and FA + DSG (FA+DSG) are projected in the same plot. Abhishek A Singh et al. LSA 2019;2:e201800115 © 2018 Singh et al.