Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model G. Dickneite, I. Pragst British.

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Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model G. Dickneite, I. Pragst British Journal of Anaesthesia Volume 102, Issue 3, Pages 345-354 (March 2009) DOI: 10.1093/bja/aen391 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 Levels of (a) FII, (b) FVII, (c) FIX, and (d) FX at baseline and after haemodilution and subsequent administration of FFP or PCC. Concentration values expressed as a percentage of the baseline median. In each panel is shown the median change from baseline in animals receiving FFP and PCC and corresponding CI. Horizontal lines within boxes indicate the medians, lower and upper box boundaries the 25th and 75th percentiles, respectively, and lower and upper error bars the 10th and 90th percentiles. Individual animal data points and horizontal lines representing the medians are displayed for the 40 ml kg−1 FFP group. CI, 95% confidence interval; FFP, fresh frozen plasma; FII, factor II; FVII, factor VII; FIX, factor IX; FX, factor X; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2009 102, 345-354DOI: (10.1093/bja/aen391) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Prothrombin time, (b) peak thrombin generation, and (c) ETP after haemodilution and subsequent administration of saline, FFP, or PCC. Graphic conventions as in Figure 1. CI, 95% confidence interval; FFP, fresh frozen plasma; ETP, endogenous thrombin potential; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2009 102, 345-354DOI: (10.1093/bja/aen391) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 Time to haemostasis following experimental (a) bone or (b) spleen trauma in animals treated with saline, FFP, or PCC. FFP, fresh frozen plasma; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2009 102, 345-354DOI: (10.1093/bja/aen391) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 Individual animal blood losses following experimental (a) bone or (b) spleen trauma in groups treated with saline, FFP or PCC. Horizontal lines depict the medians. FFP, fresh frozen plasma; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2009 102, 345-354DOI: (10.1093/bja/aen391) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions