Splicing defect of CD33 and inflammatory syndrome associated with occult bacterial infection Maria L. Balmer, MD, PhD, Beat Trüeb, PhD, Lei Zhuang, PhD,

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Presentation transcript:

Splicing defect of CD33 and inflammatory syndrome associated with occult bacterial infection Maria L. Balmer, MD, PhD, Beat Trüeb, PhD, Lei Zhuang, PhD, Emma Slack, PhD, Helmut Beltraminelli, MD, Peter Matthias Villiger, MD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 490-493.e2 (August 2013) DOI: 10.1016/j.jaci.2013.03.027 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Axial x-ray of the left hip joint, showing 2 screws in the trochanter major that were confirmed to be infected with S aureus. B, Histologic specimen of skin eruption during flare, showing subepidermal edema and a neutrophilic infiltrate. C, Macroscopic picture of maculopapulous skin eruptions during flare. Journal of Allergy and Clinical Immunology 2013 132, 490-493.e2DOI: (10.1016/j.jaci.2013.03.027) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Flow-cytometry plots showing CD33 expression on granulocytes (big population) and monocytes (small population) in patient (left) and an age- and sex-matched healthy control (right). B, Left: Analysis of CD33 mRNA from leukocytes and whole blood of the patient (P) and a healthy control (C). Bands of 958 bp (CD33M) and 577 bp (CD33m). Right: Northern blot of total RNA from leukocytes. APC, Allophycocyanin; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; SSC-A, side scatter-A. Journal of Allergy and Clinical Immunology 2013 132, 490-493.e2DOI: (10.1016/j.jaci.2013.03.027) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions