KLOTHO Allele Status and the Risk of Early-Onset Occult Coronary Artery Disease Dan E. Arking, Diane M. Becker, Lisa R. Yanek, Daniele Fallin, Daniel.

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KLOTHO Allele Status and the Risk of Early-Onset Occult Coronary Artery Disease Dan E. Arking, Diane M. Becker, Lisa R. Yanek, Daniele Fallin, Daniel P. Judge, Taryn F. Moy, Lewis C. Becker, Harry C. Dietz The American Journal of Human Genetics Volume 72, Issue 5, Pages 1154-1161 (May 2003) DOI: 10.1086/375035 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Frequency of occult CAD in the SIBS-I sample, stratified by KLOTHO genotype. P=.002 for trend (unadjusted). Error bars indicate 95% CIs. The American Journal of Human Genetics 2003 72, 1154-1161DOI: (10.1086/375035) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Frequency of occult CAD in the SIBS-I sample, stratified by hypertension and KLOTHO genotype. Left, Normotensive individuals. Right, Hypertensive individuals. Heterozygous and homozygous KL-VS allele carriers were combined because of the small numbers in the latter group after stratification for hypertension. Error bars indicate 95% CIs. The American Journal of Human Genetics 2003 72, 1154-1161DOI: (10.1086/375035) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 3 Frequency of occult CAD in the SIBS-I sample, stratified by KLOTHO genotype and current smoking status. Heterozygous and homozygous KL-VS allele carriers were combined because of the small numbers in the latter group after stratification for current smoking status. Error bars represent 95% CIs. The American Journal of Human Genetics 2003 72, 1154-1161DOI: (10.1086/375035) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 4 Relative odds of occult CAD conferred by the KL-VS allele with increasing HDL-C Levels. Blackened squares represent SIBS-I normotensive smokers. Closed triangles represent all SIBS-II normotensive individuals. The American Journal of Human Genetics 2003 72, 1154-1161DOI: (10.1086/375035) Copyright © 2003 The American Society of Human Genetics Terms and Conditions