Students: Farnaz H.Foomani, Soudeh Mostaghimi, Shima Mehrvar

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Optical imaging to assess metabolic changes in kidney transplant animal model Students: Farnaz H.Foomani, Soudeh Mostaghimi, Shima Mehrvar Advisor: Dr. Mahsa Ranji Collaborator: Dr. Allen Cowley, Department of Physiology, MCW 04/29/2019

Motivation Kidney transplant can be modeled by Uninephrectomy (UNX). Unx would result to the nephron hypertrophy. Nephron hypertrophy contributes to structural and functional changes to the remaining kidney.

Experimental Protocol Day 0 Day 3 No kidney extraction Both kidneys extraction Left kidney extraction Right kidney extraction (UNX)

3D Fluorescence Cryoimager To detect autofluorescence signals of NADH and FAD To calculate redox state NADH/FAD as an index for oxidative stress

Result and Conclusion Volumetric Redox Ratio Lower redox ratio (blue color) is related to higher oxidative stress. This study helps to find effective mitochondrial-targeted clinical interventions. As a model for transplantation it can help to treat hypertrophied kidney .

Acknowledgment Support: Collaborator: Biophotonics lab: Dr. Allen Cowley Biophotonics lab: Mahsa Ranji