IL-6 neutralization reduces T cell-mediated injury in human artery allografts. IL-6 neutralization reduces T cell-mediated injury in human artery allografts.

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Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: SOCS1 Prevents Graft Arteriosclerosis by Preserving.

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IL-6 neutralization reduces T cell-mediated injury in human artery allografts. IL-6 neutralization reduces T cell-mediated injury in human artery allografts. A, Immunohistochemical detection of human α-smooth muscle actin to define the media in representative human artery interposition grafts (5-μm transverse sections) from animals treated with IgG control (top) or anti–IL-6 mAb (bottom) for 28 d. Original magnification ×10. The areas of the lumen, total vessel, and intima are reported as the mean area in mm2 + SEM. Statistical significance was assessed via paired t test analysis (n = 8 pairs of animals from 4 independent experiments): p < 0.05. B, Immunohistochemical detection of human CD45RO+ T cells in representative human artery interposition grafts (5-μm transverse sections). Original magnification ×40. Immunostaining in A and B was performed as described in Materials and Methods. The numbers of CD45RO+ cells in the intima are reported as the mean number of CD45RO+ T cells/intima + SEM. Paired t test analysis was performed to assess statistical significance (n = 8 pairs of animals from 4 independent experiments): p < 0.05. Birgit Fogal et al. J Immunol 2011;187:6268-6280 Copyright © 2011 by The American Association of Immunologists, Inc.