Decreased brown adipose tissue (BAT) function in Deletors and the effects of nicotinamide riboside treatment for whole‐body metabolism, BAT, and liver.

Slides:

Advertisements

Similar presentations

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Advertisements

Role of TNF in fracture healing in vivo Addition of rhTNF at the fracture site on days 0 and 1 led to augmented healing, indicated by increased % callus.

Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.

Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Reduced scar formation in the injured GM of CCR2−/− mice

Volume 26, Issue 2, Pages e5 (August 2017)

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Phenotypes of GATA‐1.05/Y germline mutant embryos expressing wild‐type or mutant GATA‐1 transgenes. Phenotypes of GATA‐1.05/Y germline mutant embryos expressing.

TUG‐891 increases oxygen consumption by brown adipocytes, mediated by direct UCP1 activation and mitochondrial fragmentation TUG‐891 increases oxygen consumption.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.

TFE3 regulates glucose homeostasis

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

Mitochondrial targeting of ceramide induces lethal mitophagy in HPV(+) cells Mitochondrial targeting of ceramide induces lethal mitophagy in HPV(+) cells.

Metabolic profile of Tfe3 KO mice fed a HFD

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Metabolic profile of Tfe3 KO mice

TGF‐β1 and Sema3A are downregulated in vivo by increasing VEGF doses Muscles were harvested 7 days after implantation of V Low, V Med, and V High clones.

Increased astrocyte proliferation is paralleled with reduced infiltration of immune cells in mice with inducible SMOM2 expression in astrocytes at 5 dpi.

Supraphysiological ARSA activity in LV.hARSA‐injected NHP

Effects of GM1 on astroglial and microglial markers

Mitochondrial HMGB1 is linked to mitochondrial functions Western blot with separated cellular components from the cerebellar tissues of the three genotypes.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

TFE3 prevents diet‐induced obesity and metabolic syndrome

MI during active phase (ZT13) leads to infarct expansion and reduced cardiac function MI during active phase (ZT13) leads to infarct expansion and reduced.

Combination of OTX‐015 and PD does not induce overt toxicity

Stat3C/C mice are more prone to Th17 differentiation. A

PERK activator treatment protects neurite network

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Zc3h10 overexpression boosts mitochondrial function and density in myotubes Zc3h10 overexpression boosts mitochondrial function and density in myotubes.

IHC localization of MASP-3 protein in joints in mice with arthritis.

Nicotinamide riboside (NR) induces mitochondrial biogenesis and effectively ameliorates morphological and genetic landmarks of mitochondrial myopathy ASkeletal.

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure Shijie Liu, Tae-Hyung.

Intra‐eWAT administration of FGF21 vectors in ob/ob mice

Nec‐1 inhibits the phosphorylation and aggregation of tau

Volume 26, Issue 2, Pages e5 (August 2017)

The psoriatic phenotype of DKO

Impaired ECM protein synthesis in infarcted area of S100a4cre+/− × Fstl1flox/flox mice Impaired ECM protein synthesis in infarcted area of S100a4cre+/−

Aberrant expression of filaggrin in SASP−/− hairless mice.

EGFL7 promoted density and maturation state of glioma vessels

The preventive role of TR in HFD‐treated mice

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages.

AAV8‐hAAT‐FGF21‐mediated increased energy expenditure and decreased fat accumulation in iBAT and iWAT AAV8‐hAAT‐FGF21‐mediated increased energy expenditure.

Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149.

Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages during CVB3 infection Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages.

TGFβ signaling activity in smooth muscle cells in human left main coronary arteries with various degrees of atherosclerosis TGFβ signaling activity in.

GPR120 deficiency alters the expression of genes involved in glucose and lipid metabolism in BAT GPR120 deficiency alters the expression of genes involved.

TUG‐891 increases oxygen consumption by brown adipocytes, mediated by direct UCP1 activation and mitochondrial fragmentation TUG‐891 increases oxygen consumption.

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

ZBTB48 is required for MTFP1 expression

Therapeutic role of TR in HFD‐established diabetic mice

The CHCH domain is necessary for mitochondrial import of CHCHD10

Treatment with AZD5363 reduces the proportion of proliferating vascular endothelial cells and following RT, the influx of CD11b+ bone marrow‐derived cells.

Etifoxine modulation of T‐cell activity during EAE

The MEK inhibitor CI‐1040 reverses thickening, fibrosis, and angiogenesis in the parietal peritoneum of Cav1−/− mice upon exposure to PD fluidWT or Cav1−/−

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

GM1 decreases neuropathology and weight loss in R6/2 mice

FGFR1 and TGFβ signaling activity in smooth muscle cells in a mouse atherosclerosis model FGFR1 and TGFβ signaling activity in smooth muscle cells in a.

Bevacizumab therapy leads to reduced vessel density and increased Ang‐2 expression Bevacizumab therapy leads to reduced vessel density and increased Ang‐2.

Systemic GADD45β deletion affects metabolic regulation under conditions of heightened lipid metabolism Systemic GADD45β deletion affects metabolic regulation.

Limiting neutrophilic inflammation during active phase (ZT13) reduces MI damage Limiting neutrophilic inflammation during active phase (ZT13) reduces MI.

KlbHET mice exhibit altered estrous cycle and subfertility

Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.

Volume 21, Issue 12, Pages (December 2017)

MϕRIP140KD mice show browning in vWAT.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Insulin resistance and hepatic steatosis in ASKO mice.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Presentation transcript:

Decreased brown adipose tissue (BAT) function in Deletors and the effects of nicotinamide riboside treatment for whole‐body metabolism, BAT, and liver A, BOxygen consumption of post‐manifestation NR‐ and CD‐treated Deletor and WT mice. Decreased brown adipose tissue (BAT) function in Deletors and the effects of nicotinamide riboside treatment for whole‐body metabolism, BAT, and liver A, BOxygen consumption of post‐manifestation NR‐ and CD‐treated Deletor and WT mice. CLAMS® metabolic cage analysis, the final 24‐h recording from a total of 72 h. “Light” indicates the hours of lights on, mice inactive. “Dark” indicates the dark hours, mice active. “Cold” indicates cold exposure at 4°C for 6 h. The P‐values are from left to right: ** = 0.0092, *** = 0.001, ** = 0.0095. C, DCarbon dioxide production, as in A–B. **P = 0.013. E–HLipid content of BAT in post‐manifestation NR‐ or CD‐fed Deletors and WT mice. Oil Red O lipid staining on frozen sections with hematoxylin–eosin counterstaining. Red indicates lipid pools in BAT. (E) Deletors on CD, (F) Deletors on NR, (G) WT on CD, (H) WT mice on NR diet. I–LBAT ultrastructure in NR‐ or CD‐fed Deletors and WT mice. Electron micrographs of Deletor (I, on CD; J on NR) or WT (K on CD, L on NR). MBAT, quantification of mitochondrial crista density, as in Fig 2I. NBAT, mtDNA copy number, post‐manifestation NR‐ or CD‐fed Deletors and WT mice. Analysis by quantitative PCR. (post, n = 12 Deletor NR, n = 11 Deletor CD, n = 8 WT NR, n = 7 WT CD). OLiver, mtDNA copy number, post‐manifestation study groups (n = 12 Deletor NR, n = 11 Deletor CD, n = 8 WT NR, n = 7 WT CD). P–SLiver ultrastructure in NR‐ or CD‐fed post‐manifestation mice. Deletors (P, on CD; Q on NR) and WT mice (R on CD, S on NR). Arrows indicate ribosomes, accumulating in NR‐fed mice to close contact with mitochondria. Representative electron micrographs. Data information: The bars indicate magnification; data shown in A–D (two‐way ANOVA); all values are presented as mean ± s.e.m. (Student's t‐test). Nahid A Khan et al. EMBO Mol Med. 2014;6:721-731 © as stated in the article, figure or figure legend