Aya Matsui, Veronica A. Alvarez Neuron

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Undercover Power of Endocannabinoids: Postsynaptic Ion-Channel Modulator Aya Matsui, Veronica A. Alvarez Neuron Volume 93, Issue 6, Pages 1243-1244 (March 2017) DOI: 10.1016/j.neuron.2017.03.014 Copyright © 2017 Terms and Conditions

Figure 1 Novel and Canonical Endocannabinoid Actions in Dopamine Neurons Endocannabinoid 2-AG is synthesized upon the activation of Gq protein-coupled receptors (GqPCR), such as metabotropic glutamate, orexin, and neurotensin receptors. Through its canonical actions, 2-AG serves as a retrograde signal to activate presynaptic CB1 receptors on excitatory and inhibitory synaptic terminals. Gantz and Bean (2017) show that novel postsynaptic actions of 2-AG on Kv4.3 channels inhibit A-type potassium currents and enhance the excitability of dopamine neurons. Neuron 2017 93, 1243-1244DOI: (10.1016/j.neuron.2017.03.014) Copyright © 2017 Terms and Conditions