Reticulocyte Maturation Parameters Are Reliable Early Predictors of Hematopoietic Engraftment after Allogeneic Stem Cell Transplantation J.R. Molina,

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Reticulocyte Maturation Parameters Are Reliable Early Predictors of Hematopoietic Engraftment after Allogeneic Stem Cell Transplantation J.R. Molina, J. Sanchez-Garcia, A. Torres, M.A. Alvarez, J. Serrano, J. Casaño, P. Gomez, F. Martinez, A. Rodriguez, C. Martin Biology of Blood and Marrow Transplantation Volume 13, Issue 2, Pages 172-182 (February 2007) DOI: 10.1016/j.bbmt.2006.09.007 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Kaplan-Meier curves comparing reticulocyte engraftment days and standard absolute neutrophil count (ANC) engraftment (≥500/μL) after allogeneic transplantation. Days after transplantation are presented on the x axis and cumulative frequency of achieving engraftment is presented on the y axis; solid lines represent reticulocyte maturation parameters for engraftment and dashed lines represent standard ANC engraftment. Immature reticulocyte engraftment (IRF; ≥10%) is compared with ANC in (A) all patients with successful engraftment, (B) patients who received grafts from a sibling donor, and (C) patients who received grafts from an unrelated donor. Mean fluorescence index (MFI; ≥10) is compared with ANC in (D) all patients with successful engraftment, (E) patients who received grafts from a sibling donor, and (F) patients who received grafts from an unrelated donor. Biology of Blood and Marrow Transplantation 2007 13, 172-182DOI: (10.1016/j.bbmt.2006.09.007) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Kaplan-Meier curves comparing mean fluorescence index (MFI) engraftment (≥10) days and more stringent absolute neutrophil count (ANC) engraftment day (≥100/μL) after allogeneic transplantation. Days after transplantation are presented on the x axis and cumulative frequency of achieving engraftment is presented on the y axis; solid lines represent MFI engraftment and dashed lines represent day of achieving an ANC ≥100/μL. (A) All patients with successful engraftment and (B) patients who received grafts from a sibling donor. Biology of Blood and Marrow Transplantation 2007 13, 172-182DOI: (10.1016/j.bbmt.2006.09.007) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Kaplan-Meier curves comparing reticulocyte engraftment days and standard absolute neutrophil count (ANC) engraftment (≥500/μL) after allogeneic transplantation according to stem cell source. Days after transplantation are presented on the x axis and cumulative frequency of achieving engraftment is presented on the y axis; solid lines represent reticulocyte maturation parameter engraftment and dashed lines represent standard ANC engraftment. (A-C) Immature reticulocyte engraftment (≥10%) and (D-F) mean fluorescence index (≥10) values are presented for (A, D) bone marrow, (B, E) mobilized peripheral blood, and (C, F) umbilical cord blood. Biology of Blood and Marrow Transplantation 2007 13, 172-182DOI: (10.1016/j.bbmt.2006.09.007) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Kinetic immature reticulocyte engraftment measurement after allogeneic stem cell transplantation for patients grafted with (A) bone marrow, (B) mobilized peripheral blood, or (C) umbilical cord blood. Days before and after stem cell infusion are presented on the x axis, and mean ± SE immature reticulocyte engraftment percentages is presented on the y axis. Biology of Blood and Marrow Transplantation 2007 13, 172-182DOI: (10.1016/j.bbmt.2006.09.007) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions