Lisa H. Lerner, Abrar A. Qureshi, Bhaskar V. Reddy, Ethan A. Lerner

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Presentation transcript:

Nitric Oxide Synthase in Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome Lisa H. Lerner, Abrar A. Qureshi, Bhaskar V. Reddy, Ethan A. Lerner Journal of Investigative Dermatology Volume 114, Issue 1, Pages 196-199 (January 2000) DOI: 10.1046/j.1523-1747.2000.00816.x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Reverse transcription–PCR for iNOS in skin of SJS and TEN patients. Agarose gel electrophoresis of PCR products using primers that amplify a 281 base pair fragment of iNOS cDNA from skin of patients 1–5 with SJS or TEN. M is a 50 bp DNA marker ladder. The arrow marks the bright 350 bp band. Lanes 1–5 contain the PCR product of the respective patient. Journal of Investigative Dermatology 2000 114, 196-199DOI: (10.1046/j.1523-1747.2000.00816.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunoperoxidase staining and histology of skin biopsies from SJS/TEN patients. Lesional skin from patient 4 (a) shows intense iNOS staining of single and clustered cells in the lower epidermis and upper dermis. There is also diffuse staining of the entire epidermis. In the perilesional skin of patient 4 (b), foci of marked staining (indicated by the box and enlarged in the inset) show a pattern similar to that of the lesional skin in this patient. The staining in (a) and (b) is from iNOS as no counterstain was applied. The routine diagnostic biopsy from patient 4 (c, hematoxylin and eosin stain), shows detached epidermis with clumped dyskeratotic and necrotic keratinocytes that are most prominent in the lower epidermis. Diffuse staining for iNOS is present throughout the epidermis and in dermal inflammatory cells within the biopsy from patient 1 (d). The standard diagnostic biopsy from patient 1 (e, hematoxylin and eosin) shows detached epidermis with full thickness necrosis. In the biopsy from patient 7 (f–h), stains for iNOS (f, isotype control in insert) and leukocyte common antigen (g) show a similar distribution of positive cells in contrast to the stain for keratin 903 (h). Journal of Investigative Dermatology 2000 114, 196-199DOI: (10.1046/j.1523-1747.2000.00816.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions