Volume 69, Issue 1, Pages (January 2006)

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Presentation transcript:

Volume 69, Issue 1, Pages 10-12 (January 2006) Role of the aldosterone-sensitive distal nephron in the sodium retention associated with liver cirrhosis C.A. Ecelbarger Kidney International Volume 69, Issue 1, Pages 10-12 (January 2006) DOI: 10.1038/sj.ki.5000095 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Biphasic response of sodium retention in liver cirrhosis. Phase 1 (depicted on the left) is primarily a phase of sodium retention due to decreased activity of 11-β-HSD-2, with subsequent sodium retention by the distal tubule, as well as increased TAL sodium retention. This leads to volume expansion. In phase 2, (depicted on the right) net sodium retention is absent if rats are able to effectively ‘escape’ by means of a reduction in ENaC- and NaCl cotransporter (NCC)-mediated sodium retention. In some instances, rats are unable to effectively escape and remain in a relatively sodium-retentive phase. The determinants and modulators of escape are not well understood. Kidney International 2006 69, 10-12DOI: (10.1038/sj.ki.5000095) Copyright © 2006 International Society of Nephrology Terms and Conditions