Volume 66, Issue 1, Pages (July 2004)

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Volume 66, Issue 1, Pages 419-427 (July 2004) Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients Madhumathi Rao, Daqing Guo, Bertrand L. Jaber, Hocine Tighiouart, Brian J.G. Pereira, Vaidyanathapuram S. Balakrishnan Kidney International Volume 66, Issue 1, Pages 419-427 (July 2004) DOI: 10.1111/j.1523-1755.2004.00748.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of codon 10 and codon 25 genotypes in the cohort. Kidney International 2004 66, 419-427DOI: (10.1111/j.1523-1755.2004.00748.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Association between codon 25 genotypes and number of concomitant vascular comorbidity (ischemic heart disease, peripheral vascular disease, and cerebrovascular disease) (Mantel-Haenszel chi- square test for linear trend). Kidney International 2004 66, 419-427DOI: (10.1111/j.1523-1755.2004.00748.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Plot of the log-odds for a higher number of concomitant vascular diseases (higher nVD score) vsersus age for the G/G and G/C genotypes at codon 25. Proportional odds model adjusted for age (linear), race, codon 25, and including an interaction term for age and race. There is a significant interaction between age and codon 25 (P = 0.04). Kidney International 2004 66, 419-427DOI: (10.1111/j.1523-1755.2004.00748.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Kaplan-Meier survival plot of time to composite outcome event of first cardiac hospitalization and cardiac death, by codon 25 genotypes (log-rankP = 0.03). Kidney International 2004 66, 419-427DOI: (10.1111/j.1523-1755.2004.00748.x) Copyright © 2004 International Society of Nephrology Terms and Conditions