Volume 58, Issue 5, Pages (November 2000)

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Volume 58, Issue 5, Pages 1885-1892 (November 2000) Transforming growth factor-β1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction Yoshitaka Isaka, Michiko Tsujie, Yutaka Ando, Hiroyuki Nakamura, Yasufumi Kaneda, Enyu Imai, Masatsugu Hori Kidney International Volume 58, Issue 5, Pages 1885-1892 (November 2000) DOI: 10.1111/j.1523-1755.2000.00360.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 (A) Northern blot of cortical transforming growth factor-β1 (TGF-β1), type I collagen, and GAPDH mRNA in obstructed kidneys from rats treated with antisense oligodeoxynucleotides (ODN) for TGF-β1 (lane 1) or scrambled ODN (lane 2) untreated disease control rats (lane 3) or in contralateral normal kidneys (lane 4). (B) In situ hybridization of TGF-β1 mRNA in obstructed kidneys from untreated disease control rats (D), unilateral ureteral obstruction model rats treated with scrambled ODN (Sc) or antisense ODN (AS), or in contralateral normal kidneys (N; ×100). Kidney International 2000 58, 1885-1892DOI: (10.1111/j.1523-1755.2000.00360.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Interstitial expression of type I collagen mRNA and protein seven days after ureteral obstruction. In situ hybridization of type I collagen mRNA (A; ×200) and immunohistochemical localization of type I collagen protein (B; ×200) in obstructed kidneys from untreated disease control rats (D), unilateral ureteral obstruction model rats treated with scrambled ODN (Sc) or antisense ODN (AS) or in contralateral normal kidneys (N). Kidney International 2000 58, 1885-1892DOI: (10.1111/j.1523-1755.2000.00360.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Immunohistochemical staining for infiltrated macrophages (A; ×200) and transformed myofibroblast (B; ×100) in obstructed kidneys from untreated disease control rats (D), unilateral ureteral obstruction model rats treated with scrambled ODN (Sc) or antisense ODN (AS) or in contralateral normal kidneys (N). Kidney International 2000 58, 1885-1892DOI: (10.1111/j.1523-1755.2000.00360.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 (A) Masson's trichrome stained kidneys in obstructed kidneys from untreated disease control rats (D), unilateral ureteral obstruction model rats treated with scrambled ODN (Sc) or antisense ODN (AS), or in contralateral normal kidneys (N; ×400). (B) Morphometric analysis of relative interstitial fibrotic area. Data are expressed as mean ± SD. *P < 0.01 vs. D and Sc by analysis of variance. Kidney International 2000 58, 1885-1892DOI: (10.1111/j.1523-1755.2000.00360.x) Copyright © 2000 International Society of Nephrology Terms and Conditions