Subodh Verma, MD, PhDa, Fina Lovren, PhDb, Aaron S

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Presentation transcript:

Tetrahydrobiopterin improves endothelial function in human saphenous veins Subodh Verma, MD, PhDa, Fina Lovren, PhDb, Aaron S. Dumont, MDa, Kieren J. Mather, MDa, Andrew Maitland, MDc, Teresa M. Kieser, MDc, Christopher R. Triggle, PhDb, Todd J. Anderson, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 4, Pages 668-671 (October 2000) DOI: 10.1067/mtc.2000.109000 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Endothelium-dependent vascular relaxation to acetylcholine (ACh) in saphenous veins in the absence (control) and presence of 0.1 mmol/L of tetrahydrobiopterin (20 minutes). Data are represented as means ± SE. Vascular relaxation is expressed as the percentage of maximum relaxation in rings precontracted with the ED75 of phenylephrine. Saphenous vein segments were collected from 17 patients undergoing elective CABG operations and cut into two rings for determination of isometric dose-response curves to acetylcholine in the absence and presence of BH4. Because of limitations in vessel length, in 5 of 17 patients, only one ring could be prepared. In the presence of BH4, endothelium-dependent responses to acetylcholine were significantly augmented. Weak endothelium-dependent relaxation is typical of saphenous veins. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 668-671DOI: (10.1067/mtc.2000.109000) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Saphenous vein relaxation to the endothelium-independent vasodilator sodium nitroprusside (SNP) in the presence and absence of BH4. Sodium nitroprusside–induced vascular relaxation was not augmented by BH4, suggesting that the action of this cofactor was specific for the endothelium. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 668-671DOI: (10.1067/mtc.2000.109000) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions