Asymmetric Synthesis Dr. S. Mangalaraj Assistant Professor

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Presentation transcript:

Asymmetric Synthesis Dr. S. Mangalaraj Assistant Professor Department of Chemistry St. Joseph’s College (Autonomous) Tiruchirappalli - 2

Reaction Conversion of reactant/s into product/s Reaction Preparation known procedure available idea Synthesis unknown procedure innovative idea Asymmetric synthesis Synthesize the compound with chiral centre

Nature is Asymmetric only one not this enantiomer enantiomer enantiomers are mirror images but non superimposable

Importance of Asymmetric Synthesis retains 10% activity and even 1% of this compound destroy the activity 25micro gram trap thousands of beetles L-dopa treatment for Parkinson's disease D-dopa is toxic Pheromone of Popilia japonica (S)-citalopram antidepressant (R)-citalopram inactive

Methods of preparation of asymmetric compounds (1) Chiral pool method (2) Resolution method (1) Chiral pool method amino acid amino alcohol chiral pool compound (natural, enantiomerically pure compound) derivative of chiral pool compound amino acid amino alcohol

(2) Resolution method ephedrine (chiral reagent) crystalline salt separated soluble salt

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