Volume 129, Issue 3, Pages (September 2005)

Slides:

Advertisements

Similar presentations

Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8- Restricted Gliadin Peptides Is Associated with Celiac Disease Sophie E. Broughton,

Advertisements

Overview and pathogenesis of celiac disease Martin F. Kagnoff Gastroenterology Volume 128, Issue 4, Pages S10-S18 (April 2005) DOI: /j.gastro

Celiac Disease Genetics: Current Concepts and Practical Applications Ludvig M. Sollid, Benedicte A. Lie Clinical Gastroenterology and Hepatology Volume.

Serum immunoglobulin a from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation Tuula Halttunen, Markku Mäki.

Volume 114, Issue 4, Pages (April 1998)

Volume 129, Issue 3, Pages (September 2005)

Volume 128, Issue 2, Pages (February 2005)

Not All Effects of a Gluten-Free Diet Are Due to Removal of Gluten

Volume 149, Issue 6, Pages e2 (November 2015)

Volume 134, Issue 5, Pages e1 (May 2008)

Covering the Cover Gastroenterology

Volume 133, Issue 5, Pages (November 2007)

Leptin, obesity, and liver disease

Volume 136, Issue 3, Pages e2 (March 2009)

Volume 131, Issue 2, Pages (August 2006)

Volume 130, Issue 2, Pages (February 2006)

Volume 137, Issue 2, Pages (August 2009)

Turning Swords Into Plowshares: Transglutaminase to Detoxify Gluten

Volume 128, Issue 4, Pages (April 2005)

Ira J. Fox, Stephen C. Strom Gastroenterology

T-Cell Response to Gluten in Patients With HLA-DQ2

Volume 115, Issue 3, Pages (September 1998)

Spreading and focusing of gluten epitopes in celiac disease

Volume 132, Issue 4, Pages (April 2007)

Volume 23, Issue 1, Pages (July 2005)

Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps Atsushi Kato, PhD,

Volume 155, Issue 4, Pages (October 2018)

Volume 132, Issue 7, Pages (June 2007)

Volume 129, Issue 3, Pages (September 2005)

Volume 123, Issue 3, Pages (September 2002)

The Human Androgen Receptor X-Chromosome Inactivation Assay for Clonality Diagnostics of Natural Killer Cell Proliferations Michaël Boudewijns, Jacques.

Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps Sarah Peterson, MD, Julie A. Poposki, MS, Deepti.

Volume 128, Issue 2, Pages (February 2005)

Volume 135, Issue 6, Pages (December 2008)

Volume 144, Issue 2, Pages (February 2013)

Celiac Disease: From Pathogenesis to Novel Therapies

Volume 127, Issue 3, Pages (September 2004)

Volume 132, Issue 3, Pages (March 2007)

Volume 119, Issue 1, Pages (July 2000)

Volume 130, Issue 6, (September 2007)

Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice Bo Liu, Susan L. Tonkonogy, R. Balfour.

Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis Deepti R. Nagarkar, PhD, Julie A. Poposki,

Volume 133, Issue 2, Pages (August 2007)

Genetically engineered hybrid proteins from Parietaria judaica pollen for allergen- specific immunotherapy Roberto González-Rioja, PhD, Ignacio Ibarrola,

Volume 120, Issue 2, Pages (February 2001)

Immunopathology in RSV Infection Is Mediated by a Discrete Oligoclonal Subset of Antigen-Specific CD4+ T Cells Steven M Varga, Xiaoting Wang, Raymond.

Volume 148, Issue 3, Pages (March 2015)

Volume 149, Issue 6, Pages (November 2015)

Celiac Disease: Caught Between a Rock and a Hard Place

Volume 153, Issue 3, Pages e4 (September 2017)

Volume 135, Issue 3, Pages (September 2008)

The Rise and Fall (and Rise?) of Endoscopic Anti-Reflux Procedures

Peanut T-cell epitope discovery: Ara h 1

Volume 26, Issue 5, Pages (May 2018)

Accuracy of an immune diagnostic assay based on RD1 selected epitopes for active tuberculosis in a clinical setting: a pilot study D. Goletti, S. Carrara,

Sabah El-Ghaiesh, MSc, Joseph P

Volume 122, Issue 7, Pages (June 2002)

Volume 128, Issue 3, Pages (March 2005)

Michelle Maria Pietzak Gastroenterology

Volume 133, Issue 3, Pages (September 2007)

Volume 125, Issue 4, Pages (October 2003)

American Gastroenterological Association (AGA) Institute Technical Review on the Diagnosis and Management of Celiac Disease Alaa Rostom, Joseph A. Murray,

Volume 128, Issue 3, Pages (March 2005)

Recognition of naturally processed HTLV-1 Tax protein derived from HAM patient's PBMC. A, HTLV-1 Tax protein content was evaluated by Western blot analysis.

Cytotoxicity of p5399–107-induced CTL cells.

Volume 126, Issue 5, Pages (May 2004)

Volume 134, Issue 6, (September 2008)

Effect of bevacizumab on the proliferation of A2780 cells.

Volume 146, Issue 4, Pages (April 2014)

This Month in Gastroenterology

Presentation transcript:

Volume 129, Issue 3, Pages 797-806 (September 2005) Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients Liesbeth Spaenij–Dekking, Yvonne Kooy–Winkelaar, Peter van Veelen, Jan Wouter Drijfhout, Harry Jonker, Loek van Soest, Marinus J.M. Smulders, Dirk Bosch, Luud J.W.J. Gilissen, Frits Koning Gastroenterology Volume 129, Issue 3, Pages 797-806 (September 2005) DOI: 10.1053/j.gastro.2005.06.017 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Analysis of gluten proteins of Triticum accessions with different levels of T-cell–stimulatory epitopes in the (A, D) T-cell assay and (B, D) mAb-based competition assay. (A) Stimulation of the LMW-Glt-156–specific T-cell clone, (B) mAb-based competition assay specific for the LMW-Glt-156 T-cell epitope, (C) Western blot stained with the anti-LMW-Glt-156 T-cell epitope–specific MAb, (D) stimulation of the Glia-α2/9–specific T-cell clone, (E) mAb-based competition assay specific for the Glia-α9 T-cell epitope, and (F) Western blot stained with the anti-Glia-α9 T-cell epitope–specific mAb. The experiments shown in A and D were performed in triplicate and the mean ± SD of each measurement is shown. Gastroenterology 2005 129, 797-806DOI: (10.1053/j.gastro.2005.06.017) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Correlation between T-cell proliferation and IFN-γ production after stimulation of T-cell clones with protein extracts of 6 wheat accessions. Two T-cell clones, specific for the gluten peptides (A, B) LMW-Glt-156 and (C, D) Glia-α2/9 were tested against protein extracts of 6 wheat accessions at a concentration of 2 μg/mL protein. T-cell stimulation was determined by measurement of (A, C) proliferation and (B, D) IFN-γ production. The experiments shown in A and C were performed in triplicate and the mean ± SD of each measurement is shown. Gastroenterology 2005 129, 797-806DOI: (10.1053/j.gastro.2005.06.017) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Detection of HMW-glutenin T-cell epitope in different wheat accessions in a (A) T-cell assay and a (B) mAb-based competition assay. The T-cell responses were defined as a stimulation index ([T + APC + antigen]/[T + APC]). Gastroenterology 2005 129, 797-806DOI: (10.1053/j.gastro.2005.06.017) Copyright © 2005 American Gastroenterological Association Terms and Conditions