Neurotrophins in Skin Biology and Pathology Vladimir A. Botchkarev, Mina Yaar, Eva M.J. Peters, Siba P. Raychaudhuri, Natalia V. Botchkareva, Alessandra Marconi, Smriti K. Raychaudhuri, Ralf Paus, Carlo Pincelli  Journal of Investigative Dermatology  Volume 126, Issue 8, Pages 1719-1727 (August 2006) DOI: 10.1038/sj.jid.5700270 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Expression of NTs and their receptors in mouse and human skin. Cryostat sections of mouse and human skin were immunostained with antisera to NGF, TrkA, and p75NTR. (a–c) Mouse embryonic skin. (a) NGF and (b) TrkA expression in basal layer of epidermis (arrowheads) and hair placodes (arrows) in embryonic mouse skin. (c) p75NTR expression in the mesenchyme of developing HFs (arrows) and in Schwann cells (arrowheads) in embryonic mouse skin. (d–f) Human adult skin. (d) NGF is expressed in suprabasal keratinocytes (arrows) and in single cells of the basal epidermal layer (arrowhead). (e) TrkA expression in basal epidermal keratinoicytes (arrows). (f) p75NTR expression in basal epidermal keratinocytes with predominance in the inter-rete areas (arrows) and in cutaneous nerve fibers/Schwann cells (arrowheads). Journal of Investigative Dermatology 2006 126, 1719-1727DOI: (10.1038/sj.jid.5700270) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Scheme illustrating the effects of NTs on distinct cell populations in skin. Journal of Investigative Dermatology 2006 126, 1719-1727DOI: (10.1038/sj.jid.5700270) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions