cMΦ develop into 4 subpopulations after birth.

Slides:

Advertisements

Similar presentations

Fig. 1. TLR4 expression is much greater on macrophages than on DCs

Advertisements

by Jad I. Belle, David Langlais, Jessica C

Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice by Fernando E. Sepulveda, Sophia Maschalidi,

Volume 6, Issue 5, Pages (November 2009)

Detection of CD38+IgG1+ memory B cells adjacent to contracted GCs

Uptake of T-MPs for DC maturation and antigen presentation.

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

IRF4 is required for anabolic induction of CD4+ T cells.

Volume 31, Issue 5, Pages (November 2009)

Both haematopoietic and non‐haematopoietic compartments are involved in myocarditis development.A.Kaplan‐Meier survival curves showing survival of bone.

Volume 36, Issue 4, Pages (April 2012)

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

Fig. 3 In situ vaccination with CpG and anti-OX40 is therapeutic in a spontaneous tumor model. In situ vaccination with CpG and anti-OX40 is therapeutic.

LATS2 promotes death of lumB cells.

Volume 37, Issue 5, Pages (November 2012)

IL-21 is involved in the pathogenesis of EAM

Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4 depends on strength of α-CD3/28 signaling. Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4.

Volume 31, Issue 5, Pages (November 2009)

Volume 6, Issue 5, Pages (November 2009)

Mathieu P. Rodero, Samantha S

Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.

T exosomes bind MAdCAM-1 via RA-increased integrin α4β7.

NKG2D-dependent NK cell function in CD11c-Rae1 mice

INKTcells/CD1d regulate intestinal immunity by controlling Treg induction iNKTcells/CD1d regulate intestinal immunity by controlling Treg induction ARegulatory.

TNF Counterbalances the Emergence of M2 Tumor Macrophages

Lipid presentation by CD11c+ cells controls iNKT cell subsets

Volume 21, Issue 1, Pages (October 2017)

Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.

Elevated androgens in global ERα−/− mice decrease lung ILC2 numbers and diminish the KLRG1− ILC2 subset. Elevated androgens in global ERα−/− mice decrease.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

The mucosal environment regulates CD160 expression on IELs

Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.

FGF/ERK inhibition accelerates neural fate conversion of EpiSCs.

PD-L1 selectively marks circulating NCMs.

Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and increased T-cell activation. Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and.

Comparison of conventional NSG and hIL-7 expressing NSG humanized mice

Volume 21, Issue 1, Pages (October 2017)

CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.

Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. A:

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

Major hematopoietic cell populations in NOD mice are not affected by c-Rel deficiency. Major hematopoietic cell populations in NOD mice are not affected.

IL-27 induces expression of multiple IR by CD8+ T cells.

Volume 25, Issue 11, Pages e3 (December 2018)

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

Stress-induced monocyte accumulation in the brain and the neurovascular induction of ICAM-1 were prevented by ADX. Male C57BL/6 mice were subjected to.

Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. A–G,

CT-26 colon cancer induces the recruitment of protumor mast cells and the accumulation of MDSCs. CT-26 colon carcinoma cells (2 × 105) were injected s.c.

Vaginal CD11c+ DCs from IL-17A−/− mice are impaired in potentiating Th17 responses because of diminished IL-1β production. Vaginal CD11c+ DCs from IL-17A−/−

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

Immunization regimens that include a GLA-SE-formulated protein vaccine generate memory CD4 T cells. Immunization regimens that include a GLA-SE-formulated.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

SY-1425 induces maturation in RARA-high AML

Local proliferation of infiltrating circulating memory T cells.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Combination of R848 and anti-CD200R affects activation of tumor-infiltrating myeloid cells. Combination of R848 and anti-CD200R affects activation of tumor-infiltrating.

Impact of FRC-specific Myd88 ablation on omental FALC organization.

Mechanisms of FRC-dependent myeloid cell recruitment.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. Expansion of omental FRCs and FALC remodeling after.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

B-cell development in young Pax5+/− mice.

EC-derived SP cells are targeted by CD30.CAR T cells.

Fetal-derived γδ T cells infiltrate the meninges from birth.

Primary GBM cells are permissive to HCMV in vitro.

Presentation transcript:

cMΦ develop into 4 subpopulations after birth. cMΦ develop into 4 subpopulations after birth. (A and B) Cytometry analysis of cMΦ from adult CX3CR1GFP/+ mice. (A) FACS profiles of cMΦ populations, pregated on living single CD11b+ cells with low CD11c and Ly6C expression. (B) Mean of total and subpopulations of cMΦ in absolute numbers (left) or as percentage of total (right) as determined by bead-normalized flow cytometry. Error bars represent SEM (n = 4). (C and D) Cytometry analysis (C) and mean percentage (D) of cMΦ subpopulations from CX3CR1GFP/+ mice of indicated age. Error bars represent SEM (n = 3–4). (E) MHCII− and MHCII+ cMΦ from adult CX3CR1cre:R26-yfp mice (black line) were analyzed for YFP expression and compared with Cre− littermate controls (gray area; n = 3–4). Data in all panels are representative of at least two independent experiments. Kaaweh Molawi et al. J Exp Med 2014;211:2151-2158 © 2014 Molawi et al.