MD Tech Council – Doing Biz w/ NIH

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Presentation transcript:

MD Tech Council – Doing Biz w/ NIH Michael Shmilovich, Esq, CLP Senior Licensing & Patenting Manager National Heart, Lung, and Blood Institute Office of Technology Transfer and Development March 21, 2019

NHLBI Office of Technology Transfer and Development Nat’l Heart, Lung and Blood Institute Nat’l Inst. of Biomedical Imaging and Bioengineering Nat’l Inst. of Arthritis and Musculoskeletal and Skin Disease Nat’l Inst. on Alcohol Abuse and Alcoholism Nat’l Inst. on Deafness and Other Communication Disorders Nat’l Inst. of Environmental Health Sciences Nat’l Inst. of Nursing Research

Technology Area Highlights Cardiovascular Interventional Devices: Catheters Mitral valve repair devices Image Processing/Acquisition Technology (hardware systems and software) Microscopy Imaging Agents

Framingham Heart Study (NHLBI) Data dating back to 1948 Over 16,000 patients and their offspring Systems Approach to Biomarker Research (SABRe) in cardiovascular disease initiative: a large-scale population-based study that seeks to discover, validate, and characterize biomarkers of atherosclerotic cardiovascular disease and its major risk factors; proteomics, metabolomics, and DNA methylation  human disease NHLBI intramural lab led by Dan Levy, MD – genetic markers for: Coronary Heart Disease Pulmonary Hypertension Atherosclerosis Heart Failure

Microscopy and Imaging (NIBIB) High Resolution Optical Imaging Development of new imaging tools to study fast 3D cellular processes and structures: Cell motility Physical properties of highly-bent DNA molecules Super-resolution microscopy Single molecule fluorescence Laboratory of Molecular Imaging and Nanomedicine Construction of nanoparticle platforms for effective therapeutic delivery Evans Blue conjugates Probe synthesis for multimodality whole-body imaging of both extracellular and intracellular events Clinical translation of molecular imaging probes targeting important biological processes “All-in-one” theranostics for disease detection and monitoring as well as therapeutic delivery

NHBLI Immunotherapy Projects Childs lab Transformation of CD8+ with TIL-derived T cell receptors NK cell transformation (innate immunity against cancer) NK-mRNA Transfection Electroporation NK Lentiviral Transduction Targets: Multiple Myeloma, Renal Cell Carcinoma

SBIR-TT Program NHLBI Strategic Vision Phase I -- $225,000 Unmet scientific need Commercial potential Phase I -- $225,000 12 months max Phase II -- $1,500,000 24 month max

Contact Where to find us: Michael A. Shmilovich, Esq., CLP Office of Technology Transfer and Development 31 Center Drive Room 4A29, MSC2479 Bethesda, MD 20892-2479 o. 301.435.5019 shmilovm@mail.nih.gov Where to find us: https://www.nhlbi.nih.gov/research/tt/licensing https://www.nhlbi.nih.gov/research/tt/collaborative_opportunities