Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.

Slides:

Advertisements

Similar presentations

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Advertisements

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

Clonal bias of CD56−CD16+ NK cell subpopulations.

Expansion of Bacteroides species during colitis does not enhance TCR-specific T cell responses. Expansion of Bacteroides species during colitis does not.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

Specific depletion of TFH and LCMV-specific CD4 T cells.

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

Specific depletion of CD4-DTR–derived CD4 T cells.

Splenic CD169+ macrophages express a unique gene profile.

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

Examples of AEGIS autonomous target selection.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Resistance of CD141+ DCs to influenza virus in vivo in humanized mice.

Virus-specific T cell responses are detected in all MERS survivors.

VH usage of cross-reactive B cells induced by H5N1 or H7N9 vaccination

CD4-TEMRA cells show marked clonal expansion.

DC subset cooperation for activation of antiviral T cells.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

Blood Tfr cells show expression of follicular and regulatory markers.

Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.

Donor TRM persistence is associated with reduced clinical complications. Donor TRM persistence is associated with reduced clinical complications. Patient.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.

Analysis of plasmablast responses in one naïve and three DENV-experienced donors. Analysis of plasmablast responses in one naïve and three DENV-experienced.

Blood Tfr cells are lymphoid tissue–derived Tfr precursors.

Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.

NCMs regulate T cell survival in TLOs via PD-L1.

PD-L1 selectively marks circulating NCMs.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 4 Power and wavelet spectra of benthic δ18O.

Source-based CP BCI robotic arm control.

Variable number of CD4-CTL precursors across donors.

CD4-CTL precursor cells in the TEMRA subset.

CD4-TEMRA cells are heterogeneous across donors.

CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

CD4+CLA+CD103+ T cells in skin and blood are clonally related.

CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.

RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development. RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

Fig. 3 NK cells are enriched in ICB-sensitive tumors in mouse models and patients and are required for response. NK cells are enriched in ICB-sensitive.

MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.

MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. PBMCs.

CD25 expression identifies two transcriptionally distinct subsets of very early effector cells. CD25 expression identifies two transcriptionally distinct.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

BMS blocks functional responses in primary immune cells driven by IFNα

HRI depletion elevates γ-globin in primary erythroid CD34+ cells

Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice.

Examples of AEGIS autonomous target selection.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Human Tfr cells do not express CD25.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune.

CD4-CTL effectors share TCR clonotypes with CD4-CTL precursors.

Initial testing and characterization of cAMPr in ES cells.

CAR expression promotes tonic activation of signaling networks.

Fig. 6 Pig 5 tissue development.

Blood Tfr cells are immature but are not committed in the thymus.

Fig. 5 Proportions of EpCAM+ systemic tumor cells correlate with the clinical outcome of patients with MBC. Proportions of EpCAM+ systemic tumor cells.

Impact of FRC-specific Myd88 ablation on omental FALC organization.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 7 BEL immune response.

IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.

Fig. 3 Gene expression analysis in 48-plex drug treatment experiments.

T cell–derived IL-13 is essential for the inception of AHR.

Bb monocolonization enhances Treg population in the cLP.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

Presentation transcript:

Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived T cells with time. (A) Expression of CD69 and CD103 by CD4+ (top two rows) and CD8+ T cells (third and fourth rows) of donor or recipient origin as indicated over time after transplantation for one representative patient, P5. (B) Graphs show mean frequency (±SEM) of CD69 expression (left) or CD69/CD103 coexpression (right) by CD4+ TEM (top) or CD8+ TEM (bottom) cells in patient BAL at indicated times after transplantation, compiled from 20 patients. T cell origin designated as donor (blue) and recipient (red) based on HLA disparities (see Fig. 1); gray shaded rectangles denote 1 SD around the average frequency of CD69+ (left) and CD69+CD103+ (right) expression by control BAL T cells compiled from Fig. 2D. Expression of (C) CD49a, (D) PD-1, and (E) CD101 by BAL, airways, and parenchyma obtained from control lungs shown as representative flow cytometry plots and mean frequencies (±SEM), compiled from 14 lungs. *P = 0.02 (CD101); *P < 0.05 and **P = 0.004 (CD49a); ns (PD-1). (F) CD49a expression by donor (black) and recipient (red) CD4+ TEM (top) and CD8+ TEM (bottom) cells in patient BAL samples shown as representative flow cytometry plots (left) and in graphs showing paired frequencies from individual patient BAL samples (n = 6) at >1 month after transplantation. ***P = 0.0003 and *P = 0.007. (G) PD-1 expression by donor (black) and recipient (red) CD4+ TEM (top) and CD8+ TEM (bottom) cells in patient BAL shown as representative flow cytometry plots (left) and graphs showing paired frequencies in patient BAL samples (n = 14) >6 months after transplant. ***P = 0.0001. (H) CD101 expression by donor (black) and recipient (red) CD4+ TEM (top) and CD8+ TEM (bottom) cells in representative flow cytometry plots (left) and paired frequencies in patient BAL samples (n = 15) at >1 month after transplantation. *P = 0.02. Mark E. Snyder et al. Sci. Immunol. 2019;4:eaav5581 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works