PD-1 expression on activated regulatory T-cells (aTreg) and CD4+ T-cells. a) Frequencies of aTreg and PD-1+ aTreg in peripheral blood mononuclear cells.

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Presentation transcript:

PD-1 expression on activated regulatory T-cells (aTreg) and CD4+ T-cells. a) Frequencies of aTreg and PD-1+ aTreg in peripheral blood mononuclear cells (PBMCs) and tumour-draining lymph nodes (TDLNs) (p<0.01). b) Representative dot plot showing PD-1hi gatin... PD-1 expression on activated regulatory T-cells (aTreg) and CD4+ T-cells. a) Frequencies of aTreg and PD-1+ aTreg in peripheral blood mononuclear cells (PBMCs) and tumour-draining lymph nodes (TDLNs) (p<0.01). b) Representative dot plot showing PD-1hi gating on activated (act)CD4+ T-cells in TDLNs, and frequencies of PD-1hi actCD4 T-cells among PBMCs and TDLNs (p<0.001). c) PD-1 mean fluorescence intensity levels on aTreg, actCD4+ and cytokine-secreting (cyt)CD4+ T-cells. Paired t-tests were performed to determine statistical significance between matched PBMCs and TDLNs: **: p<0.01. Rieneke van de Ven et al. ERJ Open Res 2017;3:00110-2016 ©2017 by European Respiratory Society