Transgenic hermaphrodites expressing a sel-12::lacZ transgene.

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Transgenic hermaphrodites expressing a sel-12::lacZ transgene. Transgenic hermaphrodites expressing a sel-12::lacZ transgene. Expression is seen in neural and nonneural cells. (A) Adult. Large arrow indicates nerve ring; smaller arrows indicate muscle nuclei. (B) Adult. Arrows indicate ventral cord nuclei. (C) L3 larva. Arrows indicate nuclei of the vulval precursor cells P3.p–P8.p. (D). L2 larva. Arrows indicate the nuclei of the somatic gonadal cells Z1.ppp and Z4.aaa. sel-12 activity has been shown to influence the fates of P3.p–P8.p and Z1.ppp and Z4.aaa in sensitized genetic backgrounds (11). Compromised neural function associated with reduced activity has not yet been seen in the nerve ring or ventral cord, possibly because an appropriate sensitized genetic background has not been examined. Complete genotype: smg-1(r861) unc-54(r293); arIs17 [pRF4, pIB1Z17]. Diane Levitan et al. PNAS 1996;93:25:14940-14944 ©1996 by National Academy of Sciences