Joel Z. Melnick, Patricia A. Preisig, Robert J. Alpern, Michel Baum

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Presentation transcript:

Renal citrate metabolism and urinary citrate excretion in the infant rat Joel Z. Melnick, Patricia A. Preisig, Robert J. Alpern, Michel Baum Kidney International Volume 57, Issue 3, Pages 891-897 (March 2000) DOI: 10.1046/j.1523-1755.2000.057003891.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Sodium (Na)/citrate cotransporter activity was determined in adult (□) and infant (■) rats. Na-dependent (left bars) and Na-independent (right bars) 14C-citrate uptake was determined in renal cortical brush border membrane vesicles (N = 6). Kidney International 2000 57, 891-897DOI: (10.1046/j.1523-1755.2000.057003891.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Citrate synthase activity in adult and infant rats. Citrate synthase activity was determined spectrophotometrically as the appearance of CoA from acetyl CoA and oxaloacetate in mitochondrial suspensions (N = 6). Kidney International 2000 57, 891-897DOI: (10.1046/j.1523-1755.2000.057003891.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Adenosine 5′-triphosphate (ATP) citrate lyase activity in adult and infant rats. ATP citrate lyase activity was measured spectrophotometrically as the generation of acetylhydroxamate (N = 6). *P < 0.05. Kidney International 2000 57, 891-897DOI: (10.1046/j.1523-1755.2000.057003891.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Mitochondrial-aconitase (m-aconitase) activity in adult and infant rats. m-Aconitase activity was determined spectrophotometrically as aconitate generation from isocitrate in mitochondrial suspensions (N = 6). *P < 0.05. Kidney International 2000 57, 891-897DOI: (10.1046/j.1523-1755.2000.057003891.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Renal cortical citrate concentration in adult and infant rats. Kidneys were freeze clamped in vivo, and pulverized under liquid N2. Citrate levels were measured spectrophotometrically (N = 9). Kidney International 2000 57, 891-897DOI: (10.1046/j.1523-1755.2000.057003891.x) Copyright © 2000 International Society of Nephrology Terms and Conditions