Sulfated Glycoconjugates

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Presentation transcript:

Sulfated Glycoconjugates Overview/Structure Sulfated Glycoconjugates

Overview Carbohydrate linked to protein or lipid Glycoproteins, glycolipids External surface of the membrane

Sugars

Glycoproteins and Glycolipids Oligosaccharide side chains contain fewer than 15 sugars Branched and covalently linked O- or N-linked to proteins or lipids Cell-surface receptor molecules in cytoplasmic membrane

Glycoproteins and Glycolipids

Glycolipid Structure

Synthesis

Synthesis cont’d

Cell-cell adhesion Lectins recognize specific oligosaccharide chains Sperm-egg interactions Blood clotting Inflammatory responses

Sulfated Glycoconjugates Sulfate exists in ester linkage to oligosaccharide chains Presence in the brain, endothelial, epithelial cells Sulfated hormones

Sulfated Glycoconjugates Strong negative charge Molecular recognition processes Cystic fibrosis, cancer, osteoarthritis

Sulfated Glycoconjugates

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